Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

Guiraldello, Rafael T. [UNESP]; Martins, Marcelo L.; Mancera, Paulo F. A. [UNESP]

Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

Arquivos

WOS000376693500015.pdf (1.12 MB)

Data

2016-08-15

Autores

Guiraldello, Rafael T.

Martins, Marcelo L.

Mancera, Paulo F. A.

Editor

Elsevier B.V.

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.