Silk fibroin-antigenic peptides-YVO4:Eu3+ nanostructured thin films as sensors for hepatitis C

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dc.contributor.authorLima, Lais R. [UNESP]
dc.contributor.authorMoraes, Marli L.
dc.contributor.authorNigoghossian, Karina [UNESP]
dc.contributor.authorPeres, Maristela F.S. [UNESP]
dc.contributor.authorRibeiro, Sidney J.L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:26:47Z
dc.date.available2018-12-11T17:26:47Z
dc.date.issued2016-02-01
dc.description.abstractNanostructured films prepared by Layer-by-Layer technique and containing silk fibroin, antigenic peptide NS5A-1 derived from hepatitis C virus (HCV) NS5A protein and YVO4:Eu3+ luminescent nanoparticles, were utilized in sensing of hepatitis C. Detection system exploits the biorecognition between the antibody anti-HCV and the antigenic peptide NS5A-1 through changes in luminescence properties. Films deposition was monitored by UV-vis Absorption and Fluorescence Spectroscopy measurements at each bilayer deposited. The Eu3+ luminescence properties were evaluated in the presence of anti-HCV for optical detection of specific antibody and anti-HIV used as negative control. Significant changes in luminescence were observed in the presence of anti-HCV concentrations. A new immunosensor platform is proposed for optical detection of hepatitis C.en
dc.description.affiliationInstitute of Chemistry São Paulo State University UNESP, CP355
dc.description.affiliationInstitute of Science and Technology Federal University of São Paulo UNIFESP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University UNESP, CP355
dc.format.extent375-379
dc.identifierhttp://dx.doi.org/10.1016/j.jlumin.2015.08.039
dc.identifier.citationJournal of Luminescence, v. 170, p. 375-379.
dc.identifier.doi10.1016/j.jlumin.2015.08.039
dc.identifier.file2-s2.0-84954375578.pdf
dc.identifier.issn0022-2313
dc.identifier.scopus2-s2.0-84954375578
dc.identifier.urihttp://hdl.handle.net/11449/177721
dc.language.isoeng
dc.relation.ispartofJournal of Luminescence
dc.relation.ispartofsjr0,694
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntigenic peptide
dc.subjectEuropium
dc.subjectImmunosensor
dc.subjectLuminescent nanoparticles
dc.subjectSilk fibroin
dc.titleSilk fibroin-antigenic peptides-YVO4:Eu3+ nanostructured thin films as sensors for hepatitis Cen
dc.typeArtigo

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Artigos - Química Inorgânica - IQ