Neuropsychiatric symptoms in the prodromal stages of dementia

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dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.authorRadanovic, Marcia
dc.contributor.authorBalthazar, Marcio L. F.
dc.contributor.authorCanineu, Paulo R.
dc.contributor.authorSouza, Leonardo C. de
dc.contributor.authorForlenza, Orestes V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionPontifícia Universidade Católica de São Paulo (PUC-SP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2014-12-03T13:07:08Z
dc.date.available2014-12-03T13:07:08Z
dc.date.issued2014-05-01
dc.description.abstractPurpose of reviewTo critically discuss the neuropsychiatric symptoms in the prodromal stages of dementia in order to improve the early clinical diagnosis of cognitive and functional deterioration.Recent findingsCurrent criteria for cognitive syndrome, including Alzheimer's disease, comprise the neuropsychiatric symptoms in addition to cognitive and functional decline. Although there is growing evidence that neuropsychiatric symptoms may precede the prodromal stages of dementia, these manifestations have received less attention than traditional clinical hallmarks such as cognitive and functional deterioration. Depression, anxiety, apathy, irritability, agitation, sleep disorders, among other symptoms, have been hypothesized to represent a prodromal stage of dementia or, at least, they increase the risk for conversion from minor neurocognitive disorder to major neurocognitive disorder. Longitudinal investigations have provided increased evidence of progression to dementia in individuals with minor neurocognitive disorder when neuropsychiatric symptoms also were present.SummaryAlthough neuropsychiatric symptoms are strongly associated with a higher risk of cognitive and functional deterioration, frequently the clinician does not acknowledge these conditions as increasing the risk of dementia. When the clinician accurately diagnoses neuropsychiatric symptoms in the prodromal stage of dementia, he could early establish appropriate treatment and, may be, delay the beginning of clinical and functional deterioration.en
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, BR-13506900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Neurol, Sch Med Sci, Campinas, Brazil
dc.description.affiliationPontificia Univ Catolica Sao Paulo, Gerontol Program, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Neuropsychiat Branch, Div Neurol, Univ Hosp, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, BR-13506900 Sao Paulo, Brazil
dc.format.extent230-235
dc.identifierhttp://dx.doi.org/10.1097/YCO.0000000000000050
dc.identifier.citationCurrent Opinion In Psychiatry. Philadelphia: Lippincott Williams & Wilkins, v. 27, n. 3, p. 230-235, 2014.
dc.identifier.doi10.1097/YCO.0000000000000050
dc.identifier.issn0951-7367
dc.identifier.lattes7964386240653380
dc.identifier.urihttp://hdl.handle.net/11449/111278
dc.identifier.wosWOS:000335349500011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCurrent Opinion In Psychiatry
dc.relation.ispartofjcr4.266
dc.relation.ispartofsjr1,745
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlzheimer's diseaseen
dc.subjectmild behavior impairmenten
dc.subjectminor neurocognitive disorderen
dc.subjectneuropsychiatric symptomsen
dc.subjectprodromal dementiaen
dc.titleNeuropsychiatric symptoms in the prodromal stages of dementiaen
dc.typeArtigo
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes7964386240653380
unesp.author.orcid0000-0002-3256-6397[2]
unesp.author.orcid0000-0002-4780-444X[3]
unesp.author.orcid0000-0001-5027-9722[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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