Tannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVB

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dc.contributor.authorDaré, Regina G.
dc.contributor.authorNakamura, Celso V.
dc.contributor.authorXimenes, Valdecir F. [UNESP]
dc.contributor.authorLautenschlager, Sueli O.S.
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:36:23Z
dc.date.available2020-12-12T01:36:23Z
dc.date.issued2020-11-20
dc.description.abstractChronic and unprotect UV exposure leads to skin oxidative stress, following accumulation of damaged cellular components and downstream activation of specific signaling pathways, culminating in premature skin aging (photoaging). In this concern, polyphenols have been proposed for the prevention of skin disorders UV-generated. In the present study, we compared gallic acid (GA) and tannic acid (TA) regarding their potentials in prevent photoaging, using cell-free assays. The most promising compound was further investigated for its photoprotection abilities in UVB-irradiated L929 fibroblasts. TA was more efficient in scavenging radicals DPPH•, superoxide anion, peroxyl, nitric oxide and peroxynitrite, and to reduce ferric ions. Although GA and TA exhibited similar inhibitory activity towards collagenase, TA was more potent in inhibit elastase. In addition, TA presented a broader UV absorption spectrum. Furthermore, TA treatment in UVB-irradiated cells attenuated redox imbalance, as observed by its ability to inhibit ROS production, NADPH oxidase activation and depletion of endogenous antioxidant defense system. Moreover, TA treatment prevented cellular photodamage and subsequently photoaging, by inhibiting lipid peroxidation, depolarization of mitochondrial transmembrane potential, DNA damage, and MMP-1 expression, a protein closely related to the structural degeneration of the dermis extracellular matrix. In conclusion, the results indicate the potential of TA in act as anti-photoaging agent, due to its potent antioxidant, anti-collagenase and anti-elastase activities, and UV-absorption effects, and its ability in prevent oxidative stress, oxidative damages and MMP-1 induction in UVB-irradiated L929 fibroblasts.en
dc.description.affiliationPost-Graduate Program in Pharmaceutical Sciences State University of Maringá (UEM)
dc.description.affiliationDepartment of Basic Health Sciences State University of Maringá (UEM)
dc.description.affiliationDepartment of Chemistry Faculty of Sciences State University of São Paulo (UNESP)
dc.description.affiliationUnespDepartment of Chemistry Faculty of Sciences State University of São Paulo (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent342-355
dc.identifierhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.08.019
dc.identifier.citationFree Radical Biology and Medicine, v. 160, p. 342-355.
dc.identifier.doi10.1016/j.freeradbiomed.2020.08.019
dc.identifier.issn1873-4596
dc.identifier.issn0891-5849
dc.identifier.scopus2-s2.0-85090000866
dc.identifier.urihttp://hdl.handle.net/11449/199313
dc.language.isoeng
dc.relation.ispartofFree Radical Biology and Medicine
dc.sourceScopus
dc.subjectGallic acid
dc.subjectOxidative stress
dc.subjectPhotoaging
dc.subjectTannic acid
dc.subjectUVB
dc.titleTannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVBen
dc.typeArtigo
unesp.author.orcid0000-0001-9556-8333[1]
unesp.author.orcid0000-0003-2636-3080[3]
unesp.author.orcid0000-0001-9303-0804 0000-0001-9303-0804[4]

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