It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug

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dc.contributor.authorMesa-Arango, Ana C.
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorZaragoza, Oscar
dc.contributor.institutionInstituto de Salud Carlos III
dc.contributor.institutionUniversity of Antioquia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:20Z
dc.date.available2014-05-27T11:27:20Z
dc.date.issued2012-12-01
dc.description.abstractAmphotericin B acts through pore formation at the cell membrane after binding to ergosterol is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells. © 2012 Mesa-Arango, Scorzoni and Zaragoza.en
dc.description.affiliationMycology Reference Laboratory National Centre for Microbiology Instituto de Salud Carlos III, Majadahonda, Madrid
dc.description.affiliationGroup of Investigative Dermatology University of Antioquia, Medellín
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Araraquara-SP Laboratório de Micologia Clínica Universidade Estadual Paulista-UNESP, Araraquara, Sao Paulo
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas de Araraquara-SP Laboratório de Micologia Clínica Universidade Estadual Paulista-UNESP, Araraquara, Sao Paulo
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2012.00286
dc.identifier.citationFrontiers in Microbiology, v. 3, n. AUG, 2012.
dc.identifier.doi10.3389/fmicb.2012.00286
dc.identifier.file2-s2.0-84875503043.pdf
dc.identifier.issn1664-302X
dc.identifier.scopus2-s2.0-84875503043
dc.identifier.urihttp://hdl.handle.net/11449/73889
dc.language.isoeng
dc.relation.ispartofFrontiers in Microbiology
dc.relation.ispartofjcr4.019
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAmphotericin B
dc.subjectFungal infection
dc.subjectImmunomodulation
dc.subjectOxidative damage
dc.subjectPore
dc.titleIt only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drugen
dc.typeArtigo
dcterms.licensehttp://www.frontiersin.org/Copyright.aspx
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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