It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
dc.contributor.author | Mesa-Arango, Ana C. | |
dc.contributor.author | Scorzoni, Liliana [UNESP] | |
dc.contributor.author | Zaragoza, Oscar | |
dc.contributor.institution | Instituto de Salud Carlos III | |
dc.contributor.institution | University of Antioquia | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:27:20Z | |
dc.date.available | 2014-05-27T11:27:20Z | |
dc.date.issued | 2012-12-01 | |
dc.description.abstract | Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells. © 2012 Mesa-Arango, Scorzoni and Zaragoza. | en |
dc.description.affiliation | Mycology Reference Laboratory National Centre for Microbiology Instituto de Salud Carlos III, Majadahonda, Madrid | |
dc.description.affiliation | Group of Investigative Dermatology University of Antioquia, Medellín | |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas de Araraquara-SP Laboratório de Micologia Clínica Universidade Estadual Paulista-UNESP, Araraquara, Sao Paulo | |
dc.description.affiliationUnesp | Faculdade de Ciências Farmacêuticas de Araraquara-SP Laboratório de Micologia Clínica Universidade Estadual Paulista-UNESP, Araraquara, Sao Paulo | |
dc.identifier | http://dx.doi.org/10.3389/fmicb.2012.00286 | |
dc.identifier.citation | Frontiers in Microbiology, v. 3, n. AUG, 2012. | |
dc.identifier.doi | 10.3389/fmicb.2012.00286 | |
dc.identifier.file | 2-s2.0-84875503043.pdf | |
dc.identifier.issn | 1664-302X | |
dc.identifier.scopus | 2-s2.0-84875503043 | |
dc.identifier.uri | http://hdl.handle.net/11449/73889 | |
dc.language.iso | eng | |
dc.relation.ispartof | Frontiers in Microbiology | |
dc.relation.ispartofjcr | 4.019 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Amphotericin B | |
dc.subject | Fungal infection | |
dc.subject | Immunomodulation | |
dc.subject | Oxidative damage | |
dc.subject | Pore | |
dc.title | It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug | en |
dc.type | Artigo | |
dcterms.license | http://www.frontiersin.org/Copyright.aspx | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
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