Autologous hematopoietic stem cell transplantation for autoimmune diseases: From mechanistic insights to biomarkers

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dc.contributor.authorMalmegrim, Kelen Cristina Ribeiro
dc.contributor.authorLima-Júnior, João Rodrigues
dc.contributor.authorArruda, Lucas Coelho Marlière
dc.contributor.authorDe Azevedo, Júlia Teixeira Cottas
dc.contributor.authorDe Oliveira, Gislane Lelis Vilela [UNESP]
dc.contributor.authorOliveira, Maria Carolina
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionKarolinska Institutet
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:48:31Z
dc.date.available2019-10-06T16:48:31Z
dc.date.issued2018-11-16
dc.description.abstractPhase I/II clinical trials of autologous hematopoietic stem cell transplantation (AHSCT) have led to increased safety and efficacy of this therapy for severe and refractory autoimmune diseases (AD). Recent phase III randomized studies have demonstrated that AHSCT induces long-term disease remission in most patients without any further immunosuppression, with superior efficacy when compared to conventional treatments. Immune monitoring studies have revealed the regeneration of a self-tolerant T and B cell repertoire, enhancement of immune regulatory mechanisms, and changes toward an anti-inflammatory milieu in patients that are responsive to AHSCT. However, some patients reactivate the disease after transplantation due to reasons not yet completely understood. This scenario emphasizes that additional specific immunological interventions are still required to improve or sustain therapeutic efficacy of AHSCT in patients with AD. Here, we critically review the current knowledge about the operating immune mechanisms or established mechanistic biomarkers of AHSCT for AD. In addition, we suggest recommendations for future immune monitoring studies and biobanking to allow discovery and development of biomarkers. In our view, AHSCT for AD has entered a new era and researchers of this field should work to identify robust predictive, prognostic, treatment-response biomarkers and to establish new guidelines for immune monitoring studies and combined therapeutic interventions to further improve the AHSCT protocols and their therapeutic efficacy.en
dc.description.affiliationDepartment of Clinical Analysis Toxicology and Food Science School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo
dc.description.affiliationCenter for Cell-based Therapy Regional Hemotherapy Center of Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationBiosciences Applied to Pharmacy Program School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo
dc.description.affiliationDivision of Rheumatology Allergy Immunology and Immunotherapy Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationDepartment of Clinical Science Intervention and Technology Karolinska Institutet
dc.description.affiliationBasic and Applied Immunology Program Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Jose Do Rio Preto
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Jose Do Rio Preto
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2018.02602
dc.identifier.citationFrontiers in Immunology, v. 9, n. NOV, 2018.
dc.identifier.doi10.3389/fimmu.2018.02602
dc.identifier.issn1664-3224
dc.identifier.scopus2-s2.0-85057383552
dc.identifier.urihttp://hdl.handle.net/11449/189675
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectautoimmune diseases
dc.subjectbiomarkers
dc.subjecthematopoietic stem cell transplantation
dc.subjectimmune reconstitution
dc.subjectimmune tolerance
dc.subjectimmunoregulation
dc.titleAutologous hematopoietic stem cell transplantation for autoimmune diseases: From mechanistic insights to biomarkersen
dc.typeResenha

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Artigos - Alimentos e Nutrição - FCFAR
Artigos - Microbiologia e Imunologia - IBB