Mutagenicidade de duas espécies do gěnero Alchornea avaliadas através de ensaios com Salmonella microssomo e teste do micronúcleo

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dc.contributor.authordos Santos, Fabio V. [UNESP]
dc.contributor.authorCalvo, Tamara R. [UNESP]
dc.contributor.authorCólus, Ilce Mara S.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-27T11:24:42Z
dc.date.available2014-05-27T11:24:42Z
dc.date.issued2010-06-01
dc.description.abstractSome species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A. Juss. and Alchornea glandulosa Poepp. & Endl. are used by the local population to treat rheumatism, arthritis and muscular pains. In view of the popular use of these plants as medicines and the potential risks from their consumption, we assessed the mutagenic potential of chloroform and methanol extracts of the leaves of these plant species, employing the in vivo micronucleus test and the Ames assay. The data obtained showed that the chloroform extracts were not mutagenic. The methanol extract of A. castaneaefolia was mutagenic to strain TA98 of Salmonella typhimurium and the methanol extract of A. glandulosa to strains TA98 and TA97a. The methanol extracts of both species of Alchornea were mutagenic in vivo at the largest dose employed. The probable mutagenic agents involved were the aglycone quercetin and amentoflavone, present in both species.en
dc.description.affiliationFaculty of Pharmaceutical Sciences Department of Biological Sciences São Paulo State University, Campus Araraquara, Rodovia Araraquara-Jaú km 1, 14801-902 Araraquara-SP
dc.description.affiliationOrganic Chemistry Department Chemistry Institute São Paulo State University, PO Box 355, 14800-900 Araraquara-SP
dc.description.affiliationDepartment of General Biology Biological Sciences Center Londrina State University, Londrina, PR
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences Department of Biological Sciences São Paulo State University, Campus Araraquara, Rodovia Araraquara-Jaú km 1, 14801-902 Araraquara-SP
dc.description.affiliationUnespOrganic Chemistry Department Chemistry Institute São Paulo State University, PO Box 355, 14800-900 Araraquara-SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent382-389
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2010000300015
dc.identifier.citationBrazilian Journal of Pharmacognosy, v. 20, n. 3, p. 382-389, 2010.
dc.identifier.doi10.1590/S0102-695X2010000300015
dc.identifier.file2-s2.0-77957604792.pdf
dc.identifier.issn0102-695X
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scieloS0102-695X2010000300015
dc.identifier.scopus2-s2.0-77957604792
dc.identifier.urihttp://hdl.handle.net/11449/71703
dc.identifier.wosWOS:000280833400014
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Pharmacognosy
dc.relation.ispartofjcr1.596
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlchornea
dc.subjectAmes assay
dc.subjectMedicinal plant
dc.subjectMicronucleus
dc.subjectMutagenicity
dc.subjectchloroform extract
dc.subjectcyclophosphamide
dc.subjectmethanolic extract
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectAlchornea castaneaefolia
dc.subjectAlchornea glandulosa
dc.subjectanimal experiment
dc.subjectbacterial strain
dc.subjectcontrolled study
dc.subjectdrug cytotoxicity
dc.subjectdrug isolation
dc.subjectdrug screening
dc.subjectEuphorbia
dc.subjectfemale
dc.subjectmale
dc.subjectmicronucleus test
dc.subjectmouse
dc.subjectmutagen testing
dc.subjectmutagenicity
dc.subjectnonhuman
dc.subjectplant leaf
dc.subjectSalmonella microsome assay
dc.subjectSalmonella typhimurium
dc.titleMutagenicidade de duas espécies do gěnero Alchornea avaliadas através de ensaios com Salmonella microssomo e teste do micronúcleopt
dc.title.alternativeMutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus testen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbfar/paboutj.htm
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0003-3032-2556[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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