Pathogenesis II: Fungal responses to host responses: interaction of host cells with fungi

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dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorTaylor, M. L.
dc.contributor.authorBouchara, J. B.
dc.contributor.authorBurger, E.
dc.contributor.authorCalich, V. L. G.
dc.contributor.authorEscalante, E. D.
dc.contributor.authorHanna, S. A.
dc.contributor.authorLenzi, H. L.
dc.contributor.authorMachado, M. P.
dc.contributor.authorMiyaji, M.
dc.contributor.authorDa Silva, J. L. M.
dc.contributor.authorMota, E. M.
dc.contributor.authorRestrepo, A.
dc.contributor.authorRestrepo, S.
dc.contributor.authorTronchin, G.
dc.contributor.authorVincenzi, L. R.
dc.contributor.authorXidieh, C. F.
dc.contributor.authorZenteno, E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Nacl Autonoma Mexico
dc.contributor.institutionCHU Angers
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Oswaldo Cruz
dc.contributor.institutionChiba Univ
dc.contributor.institutionCorp Invest Biol
dc.date.accessioned2014-05-20T13:24:23Z
dc.date.available2014-05-20T13:24:23Z
dc.date.issued2000-01-01
dc.description.abstractMost of our knowledge concerning the virulence determinants of pathogenic fungi comes from the infected host, mainly from animal models and more recently from in vitro studies with cell cultures. The fungi usually present intra- and/or extracellular host-parasite interfaces, with the parasitism phenomenon dependent on complementary surface molecules. Among living organisms, this has been characterized as a cohabitation event, where the fungus is able to recognize specific host tissues acting as an attractant, creating stable conditions for its survival. Several fungi pathogenic for humans and animals have evolved special strategies to deliver elements to their cellular targets that may be relevant to their pathogenicity. Most of these pathogens express surface factors that mediate binding to host cells either directly or indirectly, in the latter case binding to host adhesion components such as extracellular matrix (ECM) proteins, which act as 'interlinking' molecules. The entry of the pathogen into the host cell is initiated by fungal adherence to the cell surface, which generates an uptake signal that may induce its cytoplasmic internalization. Once this is accomplished, some fungi are able to alter the host cytoskeletal architecture, as manifested by a rearrangement of microtubule and microfilament proteins, and this can also induce epithelial host cells to become apoptotic. It is possible that fungal pathogens induce modulation of different host cell pathways in order to evade host defences and to foster their own proliferation. For a number of pathogens, the ability to bind ECM glycoproteins, the capability of internalization and the induction of apoptosis are considered important factors in virulence. Furthermore, specific recognition between fungal parasites and their host cell targets may be mediated by the interaction of carbohydrate-binding proteins, e.g., lectins on the surface of one type of cell, probably a parasite, that combine with complementary sugars on the surface of host-cell. These interactions supply precise models to study putative adhesins and receptor-containing molecules in the context of the fungus-host interface. The recognition of the host molecules by fungi such as Aspergillus fumigatus, Paracoccidioides brasiliensis and Histoplasma capsulatum, and their molecular mechanisms of adhesion and invasion, are reviewed in this paper.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationUniv Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
dc.description.affiliationCHU Angers, Lab Parasitol Mycol, Grp Etud Interact Hote Parasite, Angers, France
dc.description.affiliationUniv São Paulo, Inst Ciências Biomed, Dept Imunol, BR-05508 São Paulo, Brazil
dc.description.affiliationInst Oswaldo Cruz, Dept Patol, BR-20001 Rio de Janeiro, Brazil
dc.description.affiliationChiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 280, Japan
dc.description.affiliationCorp Invest Biol, Medellin, Colombia
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil
dc.format.extent113-123
dc.identifierhttp://dx.doi.org/10.1080/mmy.38.s1.113.123
dc.identifier.citationMedical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 38, p. 113-123, 2000.
dc.identifier.doi10.1080/mmy.38.s1.113.123
dc.identifier.issn1369-3786
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.urihttp://hdl.handle.net/11449/7542
dc.identifier.wosWOS:000166958800013
dc.language.isoeng
dc.publisherB I O S Scientific Publishers Ltd
dc.relation.ispartofMedical Mycology
dc.relation.ispartofjcr2.799
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAspergillus fumigatuspt
dc.subjectfungus interactionpt
dc.subjectHistoplasma capsulatumpt
dc.subjectParacoccidioides brasiliensispt
dc.titlePathogenesis II: Fungal responses to host responses: interaction of host cells with fungien
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderB I O S Scientific Publishers Ltd
unesp.author.orcid0000-0002-8059-0826[1]
unesp.author.orcid0000-0001-5603-4072[18]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas