Comparison of the effects of barbiturate, benzodiazepine and ketamine on visual evoked potentials in rabbits

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dc.contributor.authorCastro, J. [UNESP]
dc.contributor.authorResende, Luan A.L. [UNESP]
dc.contributor.authorBertotti, M. F Z [UNESP]
dc.contributor.authorFonseca, Ronaldo Guimarães [UNESP]
dc.contributor.authorZanchetta, S. [UNESP]
dc.contributor.authorSchelp, Arthur Oscar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:23Z
dc.date.available2014-05-27T11:21:23Z
dc.date.issued2005-07-01
dc.description.abstractThe aim of this study was to compare the effects of barbiturate, benzodiazepine and ketamine on flash-evoked potentials (F-VEP) in adult rabbits. A total of 36 animals were studied, 16 after pentobarbital endovenous (EV) inffusion, 10 after midazolam EV administration, and 10 after ketamine EV inffusion. Pentobarbital induced triphasic F-VEP, first negative (N1), secondpositive (P1), third negative (N2) waves, all with large amplitudes and P1 with well-defined morphology. Mean P1 latency was 33ms. Midazolam induced similar but less defind triphasic waves, with mean latency of 27ms. Ketamine induced poliphasic and poorly defined F-VEP, with mean first positive (P1) latency of 27ms. Statistical analysis showed more elongated latency for the pentobarbital group than the midazolam and ketamine groups. The results of this study suggest that the pharmacological effects of pentobarbital and midazolam on GABA neurotransmission in rabbit visual cortex may be different; another neurotransmission system, possibly cholinergic, may be involved. The ketamine effect seen in rabbit visual cortex seems to be different from pentobarbital and midazolam.en
dc.description.affiliationDepartment of Anaesthesiology Botucatu School of Medicine Unesp, 18618-000 Botacatu, SP
dc.description.affiliationDepartment of Neurology and Psychiatry Botucatu School of Medicine Unesp, 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartment of Anaesthesiology Botucatu School of Medicine Unesp, 18618-000 Botacatu, SP
dc.description.affiliationUnespDepartment of Neurology and Psychiatry Botucatu School of Medicine Unesp, 18618-000 Botucatu, SP
dc.format.extent259-262
dc.identifier.citationElectromyography and Clinical Neurophysiology, v. 45, n. 5, p. 259-262, 2005.
dc.identifier.issn0301-150X
dc.identifier.lattes5248388716505709
dc.identifier.scopus2-s2.0-25444474981
dc.identifier.urihttp://hdl.handle.net/11449/68337
dc.language.isoeng
dc.relation.ispartofElectromyography and Clinical Neurophysiology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectKetamine
dc.subjectMidazolam
dc.subjectPentobarbital
dc.subjectVisual evoked potentials
dc.subject4 aminobutyric acid
dc.subjectketamine
dc.subjectmidazolam
dc.subjectpentobarbital
dc.subjectamplitude modulation
dc.subjectanimal experiment
dc.subjectcholinergic transmission
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectevoked visual response
dc.subjectfemale
dc.subjectGABAergic transmission
dc.subjectlatent period
dc.subjectnonhuman
dc.subjectvisual cortex
dc.subjectwaveform
dc.subjectwhite light
dc.subjectAnesthetics, Dissociative
dc.subjectAnimals
dc.subjectBody Temperature
dc.subjectEvoked Potentials, Visual
dc.subjectFemale
dc.subjectHypnotics and Sedatives
dc.subjectPhenobarbital
dc.subjectRabbits
dc.subjectVisual Cortex
dc.titleComparison of the effects of barbiturate, benzodiazepine and ketamine on visual evoked potentials in rabbitsen
dc.typeArtigo
unesp.author.lattes5248388716505709[6]
unesp.author.orcid0000-0001-5928-7497[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentAnestesiologia - FMBpt
unesp.departmentNeurologia, Psicologia e Psiquiatria - FMBpt

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Botucatu - FMB - Faculdade de Medicina