Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: Cyclophosphamide, Cis‐platinum, adriamycin
dc.contributor.author | Giavini, E. | |
dc.contributor.author | Lemonica, I. P. [UNESP] | |
dc.contributor.author | Lou, Y. | |
dc.contributor.author | Broccia, M. L. | |
dc.contributor.author | Prati, M. | |
dc.contributor.institution | University of Milan | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | School of Pharmacy | |
dc.date.accessioned | 2022-04-28T19:53:48Z | |
dc.date.available | 2022-04-28T19:53:48Z | |
dc.date.issued | 1990-01-01 | |
dc.description.abstract | To evaluate a possible relationship of maternal exposure to anticancer drugs during the preimplantation period to blastopathies and postimplantation embryotoxicity, CD female rats were injected intraperitoneally on day 3 of pregnancy with 15 and 30 mg/kg of cyclophosphamide (CPA), 2 and 4 mg/kg of Adriamycin (ADR), 3 and 6 mg/kg of cis‐platinum (Cis‐Pt), or with 5 ml/kg of saline. Blastocysts were collected on day 5 of gestation and evaluated for gross morphology, cell number, and micronuclei. Some females were sacrificed on day 21 of pregnancy in order to evaluate postimplantation embryotoxicity. A reduction in cell number/blastocyst was observed only in animals exposed to Cis‐Pt 6 mg/kg; vice versa, a dose‐related increase of micronuclei and of blastocysts with micronuclei was found in all groups treated with the anticancer agents. A significant increase of postimplantation loss was recorded in the groups treated with high doses of Cis‐Pt and ADR, but no clear signs of teratogenicity were observed. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company | en |
dc.description.affiliation | Department of Biology University of Milan, Milan | |
dc.description.affiliation | Department of Pharmacology Ibb Unesp, Botucatu, Sao Paulo | |
dc.description.affiliation | Zhejiang Medical University School of Pharmacy, Hangzhou, Zhejiang | |
dc.description.affiliationUnesp | Department of Pharmacology Ibb Unesp, Botucatu, Sao Paulo | |
dc.format.extent | 417-426 | |
dc.identifier | http://dx.doi.org/10.1002/tcm.1770100507 | |
dc.identifier.citation | Teratogenesis, Carcinogenesis, and Mutagenesis, v. 10, n. 5, p. 417-426, 1990. | |
dc.identifier.doi | 10.1002/tcm.1770100507 | |
dc.identifier.issn | 1520-6866 | |
dc.identifier.issn | 0270-3211 | |
dc.identifier.scopus | 2-s2.0-0025149121 | |
dc.identifier.uri | http://hdl.handle.net/11449/223915 | |
dc.language.iso | eng | |
dc.relation.ispartof | Teratogenesis, Carcinogenesis, and Mutagenesis | |
dc.source | Scopus | |
dc.subject | blastocyst | |
dc.subject | embryotoxicity | |
dc.subject | genotoxic effects | |
dc.subject | preimplantation | |
dc.subject | teratogenicity | |
dc.title | Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: Cyclophosphamide, Cis‐platinum, adriamycin | en |
dc.type | Artigo |