Implications of obesity for tendon structure, ultrastructure and biochemistry: A study on Zucker rats

Página do item simplificado
dc.contributor.authorBiancalana, Adriano
dc.contributor.authorVelloso, Licio Augusto
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.authorGomes, Laurecir
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:01:00Z
dc.date.available2014-05-20T14:01:00Z
dc.date.issued2012-02-01
dc.description.abstractThe extracellular matrix consists of collagen, proteoglycans and non-collagen proteins. The incidence of obesity and associated diseases is currently increasing in developed countries. Obesity is considered to be a disease of modern times, and genes predisposing to the disease have been identified in humans and animals. The objective of the present study was to compare the morphological and biochemical aspects of the deep digital flexor tendon of lean (Fa/Fa or Fa/fa) and genetically obese (fa/fa) Zucker rats. Ultrastructural analysis showed the presence of lipid droplets in both groups, whereas disorganized collagen fibril bundles were observed in obese animals. Lean animals presented a larger amount of non-collagen proteins and glycosaminoglycans than obese rats. We propose that the overweight and lesser physical activity in obese animals may have provoked the alterations in the composition and organization of extracellular matrix components but a genetic mechanism cannot be excluded. These alterations might be related to organizational and structural modifications in the collagen bundles that influence the mechanical properties of tendons and the progression to a pathological state. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationState Univ Campinas UNICAMP, Inst Biol, Dept Anat Cell Biol & Physiol & Biophys, BR-13083863 Campinas, SP, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, BR-13083863 Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, IBILCE, Dept Biol, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, IBILCE, Dept Biol, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/14358-5
dc.format.extent463-469
dc.identifierhttp://dx.doi.org/10.1016/j.micron.2011.11.002
dc.identifier.citationMicron. Oxford: Pergamon-Elsevier B.V. Ltd, v. 43, n. 2-3, p. 463-469, 2012.
dc.identifier.doi10.1016/j.micron.2011.11.002
dc.identifier.issn0968-4328
dc.identifier.lattes1445259468526188
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.urihttp://hdl.handle.net/11449/21552
dc.identifier.wosWOS:000299605300051
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofMicron
dc.relation.ispartofjcr1.728
dc.relation.ispartofsjr0,624
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectZucker ratsen
dc.subjectObesityen
dc.subjectTendonen
dc.subjectMorphologyen
dc.subjectGlycosaminoglycansen
dc.titleImplications of obesity for tendon structure, ultrastructure and biochemistry: A study on Zucker ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes1445259468526188
unesp.author.orcid0000-0002-0970-4288[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Biologia - IBILCE