Unsupervised method for normalization of hematoxylin-eosin stain in histological images

dc.contributor.authorAzevedo Tosta, Thaina A.
dc.contributor.authorFaria, Paulo Rogerio de
dc.contributor.authorSilva Servato, Joao Paulo
dc.contributor.authorNeves, Leandro Alves [UNESP]
dc.contributor.authorRoberto, Guilherme Freire
dc.contributor.authorMartins, Alessandro Santana
dc.contributor.authorNascimento, Marcelo Zanchetta do
dc.contributor.institutionFed Univ ABC
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniv Uberaba
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFed Inst Triangulo Mineiro
dc.date.accessioned2020-12-10T19:39:31Z
dc.date.available2020-12-10T19:39:31Z
dc.date.issued2019-10-01
dc.description.abstractHistological images stained with hematoxylin-eosin are widely used by pathologists for cancer diagnosis. However, these images can have color variations that highly influence the histological image processing techniques. To deal with this potential limitation, normalization methods are useful for color correction. In this paper, a histological image color normalization is presented by considering the biological and hematoxylin-eosin properties. To this end, the stain representation of a reference image was applied in place of the original images representation, allowing the preservation of histological structures. This proposal was evaluated on histological images with great variations of contrast, and both visual and quantitative analyzes yielded promising results. (C) 2019 Elsevier Ltd. All rights reserved.en
dc.description.affiliationFed Univ ABC, Ctr Math Comp & Cognit, Av Estados 5001, BR-09210580 Santo Andre, SP, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Biomed Sci, Dept Histol & Morphol, Av Amazonas S-N, BR-38405320 Uberlandia, MG, Brazil
dc.description.affiliationUniv Uberaba, Sch Dent, Av Nene Sabino 1801, BR-38055500 Uberaba, MG, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Comp Sci & Stat, R Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Comp Sci, Av Joao Naves de Avila 2121, BR-38400902 Uberlandia, MG, Brazil
dc.description.affiliationFed Inst Triangulo Mineiro, R Belarmino Vilela Junqueira S-N, BR-38305200 Ituiutaba, MG, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Comp Sci & Stat, R Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 427114/2016-0
dc.description.sponsorshipIdCNPq: 304848/2018-2
dc.description.sponsorshipIdCNPq: 430965/2018-4
dc.description.sponsorshipIdCNPq: 313365/2018-0
dc.description.sponsorshipIdFAPEMIG: APQ-00578-18
dc.description.sponsorshipIdCAPES: 1575210
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1016/j.compmedimag.2019.101646
dc.identifier.citationComputerized Medical Imaging And Graphics. Oxford: Pergamon-elsevier Science Ltd, v. 77, 7 p., 2019.
dc.identifier.doi10.1016/j.compmedimag.2019.101646
dc.identifier.issn0895-6111
dc.identifier.urihttp://hdl.handle.net/11449/196279
dc.identifier.wosWOS:000493216400004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComputerized Medical Imaging And Graphics
dc.sourceWeb of Science
dc.subjectHistopathological image analysis
dc.subjectNormalization
dc.subjectSpectral matching
dc.subjectSparse non-negative matrix factorization
dc.titleUnsupervised method for normalization of hematoxylin-eosin stain in histological imagesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-1783-8777[3]
unesp.author.orcid0000-0001-5883-2983[5]
unesp.author.orcid0000-0003-3537-0178[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentCiências da Computação e Estatística - IBILCEpt

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