Unsupervised method for normalization of hematoxylin-eosin stain in histological images
dc.contributor.author | Azevedo Tosta, Thaina A. | |
dc.contributor.author | Faria, Paulo Rogerio de | |
dc.contributor.author | Silva Servato, Joao Paulo | |
dc.contributor.author | Neves, Leandro Alves [UNESP] | |
dc.contributor.author | Roberto, Guilherme Freire | |
dc.contributor.author | Martins, Alessandro Santana | |
dc.contributor.author | Nascimento, Marcelo Zanchetta do | |
dc.contributor.institution | Fed Univ ABC | |
dc.contributor.institution | Universidade Federal de Uberlândia (UFU) | |
dc.contributor.institution | Univ Uberaba | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Fed Inst Triangulo Mineiro | |
dc.date.accessioned | 2020-12-10T19:39:31Z | |
dc.date.available | 2020-12-10T19:39:31Z | |
dc.date.issued | 2019-10-01 | |
dc.description.abstract | Histological images stained with hematoxylin-eosin are widely used by pathologists for cancer diagnosis. However, these images can have color variations that highly influence the histological image processing techniques. To deal with this potential limitation, normalization methods are useful for color correction. In this paper, a histological image color normalization is presented by considering the biological and hematoxylin-eosin properties. To this end, the stain representation of a reference image was applied in place of the original images representation, allowing the preservation of histological structures. This proposal was evaluated on histological images with great variations of contrast, and both visual and quantitative analyzes yielded promising results. (C) 2019 Elsevier Ltd. All rights reserved. | en |
dc.description.affiliation | Fed Univ ABC, Ctr Math Comp & Cognit, Av Estados 5001, BR-09210580 Santo Andre, SP, Brazil | |
dc.description.affiliation | Univ Fed Uberlandia, Inst Biomed Sci, Dept Histol & Morphol, Av Amazonas S-N, BR-38405320 Uberlandia, MG, Brazil | |
dc.description.affiliation | Univ Uberaba, Sch Dent, Av Nene Sabino 1801, BR-38055500 Uberaba, MG, Brazil | |
dc.description.affiliation | Sao Paulo State Univ, Dept Comp Sci & Stat, R Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil | |
dc.description.affiliation | Univ Fed Uberlandia, Fac Comp Sci, Av Joao Naves de Avila 2121, BR-38400902 Uberlandia, MG, Brazil | |
dc.description.affiliation | Fed Inst Triangulo Mineiro, R Belarmino Vilela Junqueira S-N, BR-38305200 Ituiutaba, MG, Brazil | |
dc.description.affiliationUnesp | Sao Paulo State Univ, Dept Comp Sci & Stat, R Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) | |
dc.description.sponsorshipId | CAPES: 001 | |
dc.description.sponsorshipId | CNPq: 427114/2016-0 | |
dc.description.sponsorshipId | CNPq: 304848/2018-2 | |
dc.description.sponsorshipId | CNPq: 430965/2018-4 | |
dc.description.sponsorshipId | CNPq: 313365/2018-0 | |
dc.description.sponsorshipId | FAPEMIG: APQ-00578-18 | |
dc.description.sponsorshipId | CAPES: 1575210 | |
dc.format.extent | 7 | |
dc.identifier | http://dx.doi.org/10.1016/j.compmedimag.2019.101646 | |
dc.identifier.citation | Computerized Medical Imaging And Graphics. Oxford: Pergamon-elsevier Science Ltd, v. 77, 7 p., 2019. | |
dc.identifier.doi | 10.1016/j.compmedimag.2019.101646 | |
dc.identifier.issn | 0895-6111 | |
dc.identifier.uri | http://hdl.handle.net/11449/196279 | |
dc.identifier.wos | WOS:000493216400004 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Computerized Medical Imaging And Graphics | |
dc.source | Web of Science | |
dc.subject | Histopathological image analysis | |
dc.subject | Normalization | |
dc.subject | Spectral matching | |
dc.subject | Sparse non-negative matrix factorization | |
dc.title | Unsupervised method for normalization of hematoxylin-eosin stain in histological images | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.orcid | 0000-0003-1783-8777[3] | |
unesp.author.orcid | 0000-0001-5883-2983[5] | |
unesp.author.orcid | 0000-0003-3537-0178[7] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Ciências da Computação e Estatística - IBILCE | pt |