A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE

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Data

2016-07-01

Autores

Ioca, Laura P.
Romminger, Stelamar
Santos, Mario F. C.
Bandeira, Karin F.
Rodrigues, Fabiana T.
Kossuga, Miriam H.
Nicacio, Karen J.
Ferreira, Everton L. F.
Morais-Urano, Raquel P.
Passos, Messias S.

Título da Revista

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Editor

Soc Brasileira Quimica

Resumo

The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and H-1 NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2- dimethyl-4-chromanone is herein reported for the first time as a natural product.

Descrição

Palavras-chave

fungal metabolites, rapid identification, dereplication, antiviral

Como citar

Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 39, n. 6, p. 720-731, 2016.