A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE

dc.contributor.authorIoca, Laura P.
dc.contributor.authorRomminger, Stelamar
dc.contributor.authorSantos, Mario F. C.
dc.contributor.authorBandeira, Karin F.
dc.contributor.authorRodrigues, Fabiana T.
dc.contributor.authorKossuga, Miriam H.
dc.contributor.authorNicacio, Karen J.
dc.contributor.authorFerreira, Everton L. F.
dc.contributor.authorMorais-Urano, Raquel P.
dc.contributor.authorPassos, Messias S.
dc.contributor.authorKohn, Luciana K.
dc.contributor.authorArns, Clarice W.
dc.contributor.authorSette, Lara D. [UNESP]
dc.contributor.authorBerlinck, Roberto G. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Michigan
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:06:15Z
dc.date.available2018-11-26T17:06:15Z
dc.date.issued2016-07-01
dc.description.abstractThe isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and H-1 NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2- dimethyl-4-chromanone is herein reported for the first time as a natural product.en
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Sao Francisco, BR-13045510 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Lab Virol, Inst Biol, CP 6109, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Bioquim & Microbiol, Inst Biociencias, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Bioquim & Microbiol, Inst Biociencias, BR-13506900 Rio Claro, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2010/50190-2
dc.description.sponsorshipIdFAPESP: 2013/50228-8
dc.description.sponsorshipIdFAPESP: 2011/08064-2
dc.description.sponsorshipIdFAPESP: 2008/00331-9
dc.description.sponsorshipIdFAPESP: 2013/23153-7
dc.description.sponsorshipIdCAPES: BEX 4498-14-3
dc.format.extent720-731
dc.identifierhttp://dx.doi.org/10.5935/0100-4042.20160092
dc.identifier.citationQuimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 39, n. 6, p. 720-731, 2016.
dc.identifier.doi10.5935/0100-4042.20160092
dc.identifier.fileS0100-40422016000600720.pdf
dc.identifier.issn0100-4042
dc.identifier.scieloS0100-40422016000600720
dc.identifier.urihttp://hdl.handle.net/11449/161938
dc.identifier.wosWOS:000383618200011
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofQuimica Nova
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectfungal metabolites
dc.subjectrapid identification
dc.subjectdereplication
dc.subjectantiviral
dc.titleA STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONEen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica
unesp.author.orcid0000-0003-1981-834X[3]

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