Electrospun Composite Bead-on-String Nanofibers Containing CaO2Nanoparticles and MnO2Nanosheets as Oxygen-Release Systems for Biomedical Applications

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dc.contributor.authorDos Santos, Danilo M.
dc.contributor.authorDias, Luana M. [UNESP]
dc.contributor.authorSurur, Amanda K. [UNESP]
dc.contributor.authorDe Moraes, Daniel A.
dc.contributor.authorPavarina, Ana C. [UNESP]
dc.contributor.authorFontana, Carla R. [UNESP]
dc.contributor.authorCorrea, Daniel S.
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:24:09Z
dc.date.available2023-07-29T13:24:09Z
dc.date.issued2022-10-28
dc.description.abstractOxygen-generating biomaterials have the potential to improve tissue engineering and regenerative therapeutic strategies. However, the development of such materials capable of controlling the local partial pressure of oxygen (pO2) in the long term is still a major challenge. Here we report nanostructured composite membranes comprising electrospun fibers exhibiting a bead-on-string structure as a controlled oxygen-release system for periodontitis treatment. For this, calcium peroxide nanoparticles (CaO2NPs) and manganese dioxide nanosheets (MnO2NSs) were incorporated into the structure of hydrophobic electrospun poly (lactic acid) (PLA)-based nanofibers. We use CaO2NPs as hydrogen peroxide (H2O2)-generating precursors when exposed to water, while MnO2NSs were applied as a nanozyme to catalyze the decomposition of H2O2to the final oxygen product. Our results revealed that the beads on the fibrous structure acted as reservoirs of CaO2NPs and MnO2NSs. Moreover, the composite membranes provided sustained oxygen release over 7 days, where levels were modulated by the CaO2NP content. Such constructs exhibited suitable physicochemical properties and antimicrobial activities against some bacteria (e.g., Porphyromonas gingivalis and Treponema denticola) typically associated with aggressive and chronic periodontitis. In vitro studies also revealed that the membranes were not cytotoxic toward human oral keratinocyte (Nok-si) cells as well as enhanced the cell viability when high content of CaO2NP and MnO2NS were incorporated into the fiber's structure. Taken together, our results demonstrate that the nanostructured composite membranes show potential to be employed as oxygen-release platforms for periodontal tissue regeneration.en
dc.description.affiliationNanotechnology National Laboratory for Agriculture (LNNA) Embrapa Instrumentação, São Carlos
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), Rua Humaitá, 1680-Centro, Araraquara
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01-s/n-Campos Ville, Araraquara
dc.description.affiliationSão Carlos Institute of Chemistry University of Sao Paulo, Avenue Trabalhador São-Carlense, 400, São Paulo
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), Rua Humaitá, 1680-Centro, Araraquara
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jaú, Km 01-s/n-Campos Ville, Araraquara
dc.format.extent14425-14436
dc.identifierhttp://dx.doi.org/10.1021/acsanm.2c02774
dc.identifier.citationACS Applied Nano Materials, v. 5, n. 10, p. 14425-14436, 2022.
dc.identifier.doi10.1021/acsanm.2c02774
dc.identifier.issn2574-0970
dc.identifier.scopus2-s2.0-85139567450
dc.identifier.urihttp://hdl.handle.net/11449/247726
dc.language.isoeng
dc.relation.ispartofACS Applied Nano Materials
dc.sourceScopus
dc.subjectbead-on-string fibers
dc.subjectcomposite membranes
dc.subjectelectrospinning
dc.subjectoxygen generation
dc.subjectperiodontal regeneration, hybrid materials
dc.titleElectrospun Composite Bead-on-String Nanofibers Containing CaO2Nanoparticles and MnO2Nanosheets as Oxygen-Release Systems for Biomedical Applicationsen
dc.typeArtigo
unesp.author.orcid0000-0002-3884-3236[1]
unesp.author.orcid0000-0002-5592-0627[7]
unesp.departmentAnálises Clínicas - FCFpt

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Artigos - Materiais Odontológicos e Prótese - FOAR
Araraquara - FCF - Faculdade de Ciências Farmacêuticas