Controle da infecção fúngica pelos extratos de alho (Allium sativum L.) e modulação da atividade de macrófagos peritoneais em modelo murino de esporotricose

Página do item simplificado
dc.contributor.authorBurian, J. P. [UNESP]
dc.contributor.authorSacramento, L. V.S. [UNESP]
dc.contributor.authorCarlos, I. Z. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:15:13Z
dc.date.available2018-12-11T17:15:13Z
dc.date.issued2017-11-01
dc.description.abstractGarlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones. Sporothrix schenckii, the causing agent of Sporotrichosis (most common subcutaneous mycosis in Latin America), is dimorphic fungus, of saprophytic life in soil or plants, infecting people and animals mainly through skin injuries and bruises. The main of this work was to evaluate the influence of garlic consuming on immune modulation of healthy and infected Swiss mice in induced way by S. schenckii, since these animals functioning of peritoneal macrophages as well as the nitric oxide and cytokines’ production (IL-1β, IL-10 and IL-12) and to evaluate the antifungal potential of garlic with S. schenckii through minimum inhibitory concentration test and colony-forming units. The results showed that garlic offers antifungal potential with S. schenckii. The oral taking of garlic extracts influences the releasing of cytokines by macrophages, regular consuming shows anti-inflammatory effect, and its acute use may take to an inflammatory response. Mice that consumed garlic responded more effectively to fight against the infection.en
dc.description.affiliationDepartment of Foods and Nutrition School of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP, Rodovia Araraquara-Jaú, Km 1
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP, Rodovia Araraquara-Jaú, Km 1
dc.description.affiliationUnespDepartment of Foods and Nutrition School of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP, Rodovia Araraquara-Jaú, Km 1
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP, Rodovia Araraquara-Jaú, Km 1
dc.format.extent848-855
dc.identifierhttp://dx.doi.org/10.1590/1519-6984.03716
dc.identifier.citationBrazilian Journal of Biology, v. 77, n. 4, p. 848-855, 2017.
dc.identifier.doi10.1590/1519-6984.03716
dc.identifier.fileS1519-69842017000400848.pdf
dc.identifier.issn1678-4375
dc.identifier.issn1519-6984
dc.identifier.scieloS1519-69842017000400848
dc.identifier.scopus2-s2.0-85030685667
dc.identifier.urihttp://hdl.handle.net/11449/175302
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Biology
dc.relation.ispartofsjr0,523
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectGarlic
dc.subjectInterleukin
dc.subjectMacrophage
dc.subjectSporothrix schenckii
dc.subjectSporotrichosis
dc.titleControle da infecção fúngica pelos extratos de alho (Allium sativum L.) e modulação da atividade de macrófagos peritoneais em modelo murino de esporotricosept
dc.title.alternativeFungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosisen
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1519-69842017000400848.pdf
Tamanho:
1.98 MB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos - Alimentos e Nutrição - FCFAR
Artigos - Análises Clínicas - FCFAR