Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. In Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dualenergy x-ray absorptiometry (DEXA) and mechanical testing

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dc.contributor.authorLucinda, Leda Marília Fonseca
dc.contributor.authorAarestrup, Beatriz J. V.
dc.contributor.authorReboredo, Maycon M.
dc.contributor.authorPains, Thais D. A.
dc.contributor.authorChaves, Raphael Z.
dc.contributor.authorReis, João E. P.
dc.contributor.authorLouzada, Mário J. Q. [UNESP]
dc.contributor.authorGuerra, Martha O.
dc.contributor.institutionUniversidade Federal de Juiz de Fora/UFJF
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:50:59Z
dc.date.available2018-12-11T16:50:59Z
dc.date.issued2017-10-01
dc.description.abstractEvaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.en
dc.description.affiliationCentro de Biologia da Reprodução Universidade Federal de Juiz de Fora/UFJF, São Pedro, Caixa Postal 328
dc.description.affiliationFaculdade de Medicina Veterinária de Araçatuba Universidade do Estado de São Paulo/UNESP, Rua Clovis Pestana, 793
dc.description.affiliationFaculdade de Medicina Universidade Federal de Juiz de Fora/UFJF, Avenida Eugênio do Nascimento, s/n, Caixa Postal 328
dc.description.affiliationUnespFaculdade de Medicina Veterinária de Araçatuba Universidade do Estado de São Paulo/UNESP, Rua Clovis Pestana, 793
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdFAPEMIG: 173/08
dc.description.sponsorshipIdFAPEMIG: APQ-00154-11
dc.format.extent2833-2841
dc.identifierhttp://dx.doi.org/10.1590/0001-3765201720160479
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 89, n. 4, p. 2833-2841, 2017.
dc.identifier.doi10.1590/0001-3765201720160479
dc.identifier.fileS0001-37652017000602833.pdf
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scieloS0001-37652017000602833
dc.identifier.scopus2-s2.0-85038407780
dc.identifier.urihttp://hdl.handle.net/11449/170479
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.relation.ispartofsjr0,418
dc.relation.ispartofsjr0,418
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBone density
dc.subjectDEXA scan
dc.subjectGinkgo biloba
dc.subjectOsteoporosis
dc.titleEvaluation of the anti-osteoporotic effect of Ginkgo biloba L. In Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dualenergy x-ray absorptiometry (DEXA) and mechanical testingen
dc.typeArtigo

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