New approaches regarding the in vitro maturation of oocytes: Manipulating cyclic nucleotides and their partners in crime

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dc.contributor.authorBotigelli, Ramon Cesar
dc.contributor.authorRazza, Eduardo Montanari
dc.contributor.authorPioltine, Elisa Mariano
dc.contributor.authorGouveia Nogueira, Marcelo Fábio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:05:44Z
dc.date.available2022-04-28T19:05:44Z
dc.date.issued2017-01-01
dc.description.abstractSeveral discoveries have been described recently (5-10 years) about the biology of ovarian follicles (oocyte, cumulus cells and granulosa cells), including new aspects of cellular communication, the control of oocyte maturation and the acquisition of oocyte competence for fertilization and further embryo development. These advances are nourishing assisted reproduction techniques (ART) with new possibilities, in which novel culture systems are being developed and tested to improve embryo yield and quality. This mini-review aims to describe how the recent knowledge on the physiological aspects of mammalian oocyte is reflecting as original or revisited approaches into the context of embryo production. These new insights include recent findings on the mechanisms that control oocyte maturation, especially modulating intraoocyte levels of cyclic nucleotides during in vitro maturation using endogenous or exogenous agents. In this mini-review we also discuss the positive and negative effects of these manipulations on the outcoming embryo.en
dc.description.affiliationDepartment of Pharmacology Institute of Bioscience University of São Paulo State
dc.description.affiliationDepartment of Biological Sciences Faculty of Sciences and Letters University of São Paulo State
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/50533-2
dc.description.sponsorshipIdFAPESP: 2013/05083-1
dc.format.extent35-44
dc.identifierhttp://dx.doi.org/10.5935/1518-0557.20170010
dc.identifier.citationJornal Brasileiro de Reproducao Assistida, v. 21, n. 1, p. 35-44, 2017.
dc.identifier.doi10.5935/1518-0557.20170010
dc.identifier.issn1518-0557
dc.identifier.issn1517-5693
dc.identifier.scopus2-s2.0-85015417487
dc.identifier.urihttp://hdl.handle.net/11449/220809
dc.language.isoeng
dc.relation.ispartofJornal Brasileiro de Reproducao Assistida
dc.sourceScopus
dc.subjectCumulus cells
dc.subjectCyclic nucleotides
dc.subjectIn vitro oocyte maturation techniques
dc.subjectOocyte in vitro maturation
dc.subjectOocytes
dc.titleNew approaches regarding the in vitro maturation of oocytes: Manipulating cyclic nucleotides and their partners in crimeen
dc.typeResenha

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