Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme

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dc.contributor.authorTorres, Maria Conceicao M.
dc.contributor.authorPinto, Francisco das Chagas L.
dc.contributor.authorBraz-Filho, Raimundo
dc.contributor.authorSilveira, Edilberto R.
dc.contributor.authorPessoa, Otilia Deusdenia L.
dc.contributor.authorJorge, Roberta Jeane Bezerra
dc.contributor.authorXimenes, Rafael Matos
dc.contributor.authorAzul Monteiro, Helena Serra
dc.contributor.authorAzul Monteiro Evangelista, Janaina Serra
dc.contributor.authorDiz-Filho, Eduardo B. S.
dc.contributor.authorToyama, Marcos Hikari [UNESP]
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionUniv Estadual Ceara
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:12:21Z
dc.date.available2014-05-20T13:12:21Z
dc.date.issued2011-10-01
dc.description.abstractThree new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including ID and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A(2) activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2.en
dc.description.affiliationUniversidade Federal do Ceará (UFC), Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal do Ceará (UFC), Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Ceara, Fac Vet, BR-60740000 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Bioquim, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, BR-11330900 Sao Vicente, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPrograma de Apoio aos Núcleos de Excelência (PRONEX)
dc.format.extent2168-2173
dc.identifierhttp://dx.doi.org/10.1021/np200479a
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 10, p. 2168-2173, 2011.
dc.identifier.doi10.1021/np200479a
dc.identifier.issn0163-3864
dc.identifier.lattes8573195327542061
dc.identifier.urihttp://hdl.handle.net/11449/327
dc.identifier.wosWOS:000296206500019
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAntiophidic Solanidane Steroidal Alkaloids from Solanum campaniformeen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes8573195327542061
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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São Vicente - IBCLP - Instituto de Biociências