Oxidative stress monitoring in in vitro and in vivo models

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dc.contributor.authorLima, Thania Rios Rossi [UNESP]
dc.contributor.authorSales, Bianca Camargo Penteado [UNESP]
dc.contributor.authorPereira, Lilian Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCenter for Evaluation of Environmental Impact on Human Health (TOXICAM)
dc.date.accessioned2020-12-12T02:19:43Z
dc.date.available2020-12-12T02:19:43Z
dc.date.issued2020-01-01
dc.description.abstractIn aerobic organisms, cellular respiration is an essential process that is divided into several steps. The third and last step is called oxidative phosphorylation, which occurs in the mitochondria, specifically in the inner mitochondrial membrane. The mitochondria are considered the cell “powerhouse” because they generate energy through oxidative phosphorylation, which is the main energy source in aerobic organisms. The generated energy is stored in the ATP molecule and is used to maintain various biological processes. Conversely, the mitochondria are also the primary site for reactive oxygen species (ROS) production. If ROS are produced beyond the capacity of antioxidant systems to neutralize them, they induce oxidative stress. This condition is harmful for macromolecules and can lead to cell death. Oxidative stress and its consequences can be monitored by many assays that employ in vitro and in vivo models, which will be discussed throughout this chapter.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationCenter for Evaluation of Environmental Impact on Human Health (TOXICAM)
dc.description.affiliationFaculty of Agronomic Sciences of Botucatu Department of Bioprocesses and Biotechnology São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationUnespFaculty of Agronomic Sciences of Botucatu Department of Bioprocesses and Biotechnology São Paulo State University (UNESP)
dc.format.extent163-178
dc.identifierhttp://dx.doi.org/10.1007/978-981-15-1568-2_10
dc.identifier.citationRole of Oxidative Stress in Pathophysiology of Diseases, p. 163-178.
dc.identifier.doi10.1007/978-981-15-1568-2_10
dc.identifier.scopus2-s2.0-85089639216
dc.identifier.urihttp://hdl.handle.net/11449/200925
dc.language.isoeng
dc.relation.ispartofRole of Oxidative Stress in Pathophysiology of Diseases
dc.sourceScopus
dc.subjectCellular culture
dc.subjectOxidative stress monitoring
dc.subjectROS
dc.subjectZebrafish
dc.titleOxidative stress monitoring in in vitro and in vivo modelsen
dc.typeCapítulo de livro

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