Circulating heme oxygenase-1: Not a predictor of preeclampsia but highly expressed in pregnant women who subsequently develop severe preeclampsia

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dc.contributor.authorSandrim, Valéria C. [UNESP]
dc.contributor.authorCaldeira-Dias, Mayara [UNESP]
dc.contributor.authorBettiol, Heloisa
dc.contributor.authorBarbieri, Marco Antonio
dc.contributor.authorCardoso, Viviane Cunha
dc.contributor.authorCavalli, Ricardo Carvalho
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:02:45Z
dc.date.available2019-10-06T16:02:45Z
dc.date.issued2018-01-01
dc.description.abstractPreeclampsia is the major cause of maternal and fetal deaths worldwide. Circulating biomarker concentrations to predict preeclampsia must be determined. Therefore, the objective was to evaluate heme oxygenase-1 (HO-1) concentration in both plasma and urine samples from pregnant women before the development of preeclampsia and to identify a potential biomarker for preeclampsia development. We performed a case-control study nested in a prospective study cohort at University Hospital of the Ribeirao Preto Medical School, University of São Paulo (HCFMRP-USP), Ribeirao Preto, Brazil. Of 1400 pregnant women evaluated at 20-25 weeks of gestation, 460 delivered in hospitals outside our institution. Of 940 pregnant women who completed the protocol, 30 developed preeclampsia (cases, 14 cases of severe preeclampsia and 16 cases of mild preeclampsia). Healthy pregnant women (controls, n = 90) were randomly selected from the remaining 910 participants. HO-1 concentration was evaluated in plasma/urine samples by using a commercial enzyme-linked immunosorbent assay kit. We found similar HO-1 levels in the plasma and urine for case and control groups. In the subgrouped preeclampsia, lower plasma HO-1 levels were found in mild compared with severe preeclampsia. We conclude that plasma HO-1 levels were not altered at 20-25 weeks of gestation before the manifestation of preeclampsia symptoms. Pregnant women who subsequently develop severe preeclampsia show higher expression of HO-1. This may be indicative of important underlying pathophysiologic mechanisms that differentiate between mild and severe preeclampsia and may possibly be related to a higher prooxidative status even before the development of clinical symptoms.en
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Pediatrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo
dc.description.affiliationDepartment of Obstetric and Gynecology Faculty of Medicine of Ribeirao Preto University of Sao Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1155/2018/6035868
dc.identifier.citationOxidative Medicine and Cellular Longevity, v. 2018.
dc.identifier.doi10.1155/2018/6035868
dc.identifier.issn1942-0994
dc.identifier.issn1942-0900
dc.identifier.scopus2-s2.0-85055613760
dc.identifier.urihttp://hdl.handle.net/11449/188273
dc.language.isoeng
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleCirculating heme oxygenase-1: Not a predictor of preeclampsia but highly expressed in pregnant women who subsequently develop severe preeclampsiaen
dc.typeArtigo

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