A simplified reflectometric method for the rapid determination of dipyrone in pharmaceutical formulations

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dc.contributor.authorWeinert, Patrícia L. [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:35Z
dc.date.available2014-05-27T11:22:35Z
dc.date.issued2007-09-06
dc.description.abstractThis paper describes a simple, portable and environmentally friendly method for the rapid determination of dipyrone in pharmaceuticals by using diffuse reflectance spectroscopy. The proposed method is based on the reflectance measurements of the orange compound produced from the spot test reaction between dipyrone and p-dimethylaminocinnamaldehyde (p-DAC), in acid medium, using a filter paper as solid support. Experimental design methodologies were used to optimize the measurement conditions. All reflectance measurements were carried out at 510 nm and the linear range was from 1.42 × 10-4-2.85 × 10-3 mol L-1, with a correlation coefficient of 0.999. The limit of detection (LOD) and the limit of quantification (LOQ) were 1.20 × 10-5 mol L-1 and 4.00 × 10-5 mol L-1, respectively. The intraday precision and interday precision were studied for 10 replicate analyses of 7.90 × 10-4 mol L-1 dipyrone solution. The coefficients of variation were 1.1 and 0.9%, respectively. The proposed method was applied successfully to the determination of dipyrone in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in formulations. The results obtained by the proposed method were favorably compared with those given by the Brazilian Pharmacopoeia procedure at 95% confidence level. ©2007 Sociedade Brasileira de Química.en
dc.description.affiliationInstituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.format.extent846-854
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532007000400026
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 18, n. 4, p. 846-854, 2007.
dc.identifier.doi10.1590/S0103-50532007000400026
dc.identifier.file2-s2.0-34548296994.pdf
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.lattes5978908591853524
dc.identifier.lattes3192125098361121
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.scieloS0103-50532007000400026
dc.identifier.scopus2-s2.0-34548296994
dc.identifier.urihttp://hdl.handle.net/11449/69881
dc.identifier.wosWOS:000249204300026
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDipyrone
dc.subjectPharmaceutical formulations
dc.subjectReflectance spectroscopy
dc.subjectSpot test
dc.titleA simplified reflectometric method for the rapid determination of dipyrone in pharmaceutical formulationsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jbchs/iaboutj.htm
unesp.author.lattes5978908591853524
unesp.author.lattes3192125098361121
unesp.author.orcid0000-0003-0197-7369[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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