Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis

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dc.contributor.authorSouza, Vanessa G. P. [UNESP]
dc.contributor.authorForder, Aisling
dc.contributor.authorBrockley, Liam J.
dc.contributor.authorPewarchuk, Michelle E.
dc.contributor.authorTelkar, Nikita
dc.contributor.authorde Araújo, Rachel Paes [UNESP]
dc.contributor.authorTrejo, Jessica
dc.contributor.authorBenard, Katya
dc.contributor.authorSeneda, Ana Laura [UNESP]
dc.contributor.authorMinutentag, Iael W. [UNESP]
dc.contributor.authorErkan, Melis
dc.contributor.authorStewart, Greg L.
dc.contributor.authorHasimoto, Erica N. [UNESP]
dc.contributor.authorGarnis, Cathie
dc.contributor.authorLam, Wan L.
dc.contributor.authorMartinez, Victor D.
dc.contributor.authorReis, Patricia P. [UNESP]
dc.contributor.institutionBritish Columbia Cancer Research Institute
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionBritish Columbia Children’s Hospital Research Institute
dc.contributor.institutionIWK Health Centre
dc.contributor.institutionDalhousie University
dc.contributor.institutionBeatrice Hunter Cancer Research Institute
dc.contributor.institutionUniversity of British Columbia
dc.date.accessioned2023-07-29T13:56:42Z
dc.date.available2023-07-29T13:56:42Z
dc.date.issued2023-05-01
dc.description.abstractLiquid biopsies have emerged as a promising tool for the detection of metastases as well as local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a patient’s blood, urine, or other body fluids for the detection of biomarkers, including circulating tumor cells or tumor-derived DNA/RNA that have been shed into the bloodstream. Studies have shown that liquid biopsies can detect lung cancer metastases with high accuracy and sensitivity, even before they are visible on imaging scans. Such tests are valuable for early intervention and personalized treatment, aiming to improve patient outcomes. Liquid biopsies are also minimally invasive compared to traditional tissue biopsies, which require the removal of a sample of the tumor for further analysis. This makes liquid biopsies a more convenient and less risky option for patients, particularly those who are not good candidates for invasive procedures due to other medical conditions. While liquid biopsies for lung cancer metastases and relapse are still being developed and validated, they hold great promise for improving the detection and treatment of this deadly disease. Herein, we summarize available and novel approaches to liquid biopsy tests for lung cancer metastases and recurrence detection and describe their applications in clinical practice.en
dc.description.affiliationBritish Columbia Cancer Research Institute
dc.description.affiliationMolecular Oncology Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP)
dc.description.affiliationBritish Columbia Children’s Hospital Research Institute
dc.description.affiliationDepartment of Pathology and Laboratory Medicine IWK Health Centre
dc.description.affiliationDepartment of Pathology Faculty of Medicine Dalhousie University
dc.description.affiliationBeatrice Hunter Cancer Research Institute
dc.description.affiliationDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP
dc.description.affiliationDivision of Otolaryngology Department of Surgery University of British Columbia
dc.description.affiliationUnespMolecular Oncology Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP
dc.description.sponsorshipCentre for Blood Research, University of British Columbia
dc.description.sponsorshipFaculty of Pharmaceutical Sciences, University of British Columbia
dc.description.sponsorshipInstitute of Mental Health, University of British Columbia
dc.description.sponsorshipStewart Blusson Quantum Matter Institute, University of British Columbia
dc.description.sponsorshipUniversity of British Columbia
dc.description.sponsorshipBC Cancer Foundation
dc.description.sponsorshipDepartment of Psychiatry, Faculty of Medicine, University of British Columbia
dc.description.sponsorshipFaculty of Medicine, University of British Columbia
dc.description.sponsorshipSchool of Nursing, University of British Columbia
dc.description.sponsorshipUniversity of British Columbia Graduate School
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCAPES: 88887.691765/2022-00
dc.description.sponsorshipIdCanadian Institutes of Health Research: FRN-143345
dc.description.sponsorshipIdCanadian Institutes of Health Research: FRN-183775
dc.identifierhttp://dx.doi.org/10.3390/ijms24108894
dc.identifier.citationInternational Journal of Molecular Sciences, v. 24, n. 10, 2023.
dc.identifier.doi10.3390/ijms24108894
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85160373589
dc.identifier.urihttp://hdl.handle.net/11449/248894
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectCTCs
dc.subjectctDNA
dc.subjectliquid biopsy
dc.subjectlung cancer
dc.subjectmetastasis
dc.subjectrecurrence
dc.titleLiquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasisen
dc.typeResenha
unesp.author.orcid0000-0002-1561-1651[1]
unesp.author.orcid0000-0002-3520-2353[5]
unesp.author.orcid0000-0003-0712-8739[6]
unesp.author.orcid0000-0003-1308-4410[7]
unesp.author.orcid0000-0002-5177-0887[9]
unesp.author.orcid0000-0002-2087-5686[10]
unesp.author.orcid0000-0003-3775-3797[17]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentCirurgia e Ortopedia - FMBpt

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Botucatu - FMB - Faculdade de Medicina