Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty

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dc.contributor.authorLeite, Gabriel Adan Araujo [UNESP]
dc.contributor.authorde Barros, Jorge Willian Franco [UNESP]
dc.contributor.authorMartins, Airton da Cunha
dc.contributor.authorAnselmo-Franci, Janete Aparecida
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorKempinas, Wilma De Grava [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:48:02Z
dc.date.available2019-10-06T16:48:02Z
dc.date.issued2019-02-01
dc.description.abstractDyslipidemias are occurring earlier in the population due to the augmentation of obesity. Rosuvastatin reduces cholesterol and triglycerides; however, previous studies have shown that it may affect male reproduction. Ascorbic acid (AA), an antioxidant compound, plays a protective role in the male reproductive system. This study aimed to evaluate whether pre-pubertal exposure to rosuvastatin may impair testicular structure and antioxidant status in male rats and if supplementation with AA may alleviate these damages. Male rats were randomly divided into six experimental groups (n = 10) on postnatal day (PND) 23 and received the different treatments by gavage from PND 23 to 53. The experimental groups received vehicle (saline solution 0.9%), 3 or 10 mg/kg/day of rosuvastatin diluted in saline solution 0.9%, supplementation with 150 mg/day of AA, 3 mg/kg/day of rosuvastatin in association with 150 mg/day of AA or 10 mg/kg/day of rosuvastatin associated with 150 mg/day of AA. Testicular parameters were assessed on PND 53 and 110. There were diminished androgen receptors staining in the Sertoli cells and increased germ cell death in rosuvastatin-exposed groups, in both periods. Spermatids showed lower estrogen alpha-receptors staining in the group exposed to 10 mg of statin at adulthood. There were androgen depletion and increased lipid peroxidation and catalase activity in statin-exposed groups. Rosuvastatin exposure during pre-puberty impaired testicular structure, steroid receptor distribution and increased oxidative stress; however, AA was able to ameliorate the impairment provoked by statin exposure.en
dc.description.affiliationGraduate Program in Cell and Structural Biology Institute of Biology State University of Campinas – UNICAMP
dc.description.affiliationDepartment of Morphology São Paulo State University (Unesp) Institute of Biosciences
dc.description.affiliationDepartment of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo – USP
dc.description.affiliationDepartment of Morphology Physiology and Basic Pathology School of Dentistry of Ribeirão Preto USP—University of São Paulo Ribeirão Preto
dc.description.affiliationUnespDepartment of Morphology São Paulo State University (Unesp) Institute of Biosciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 013/22495-1
dc.description.sponsorshipIdCNPq: 308842/2013-8
dc.format.extent305-321
dc.identifierhttp://dx.doi.org/10.1002/jat.3720
dc.identifier.citationJournal of Applied Toxicology, v. 39, n. 2, p. 305-321, 2019.
dc.identifier.doi10.1002/jat.3720
dc.identifier.issn1099-1263
dc.identifier.issn0260-437X
dc.identifier.scopus2-s2.0-85053681480
dc.identifier.urihttp://hdl.handle.net/11449/189663
dc.language.isoeng
dc.relation.ispartofJournal of Applied Toxicology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectmale reproduction
dc.subjectstatin
dc.subjecttestis
dc.subjecttoxicology
dc.subjectvitamin C
dc.titleAscorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-pubertyen
dc.typeArtigo
unesp.author.orcid0000-0002-9437-6310[1]

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