Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)

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dc.contributor.authorNegri, K. M.S. [UNESP]
dc.contributor.authorMalafronte, N.
dc.contributor.authorCerto, G.
dc.contributor.authorD’Angelo, V.
dc.contributor.authorRapisarda, A.
dc.contributor.authorBauab, T. M. [UNESP]
dc.contributor.authorGermanò, M. P.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Salerno
dc.contributor.institutionUniversity of Messina
dc.date.accessioned2022-04-28T19:06:20Z
dc.date.available2022-04-28T19:06:20Z
dc.date.issued2017-04-30
dc.description.abstractAstronium urundeuva (Fr. All.) Engl. (aroeira-do-sertão) (Anacardiaceae) is an arboreal species typical of northeast brazilian savanna popularly used for its anti-inflammatory, antimicrobial, anti-ulcerogenic and healing properties. In this study the effects of A. urundeuva on in vivo angiogenesis are evaluated. Stem bark (AUS) and leaves (AUL) extracts (EtOH 70%) are investigated on zebrafish embryos and chick chorioallantoic membrane (CAM). Results of the biological screening show that AUS extracts induce a weak anti-angiogenic response in both experimental models. Conversely, AUL extracts at 25 and 50 μg/mL enhance vessel formation in zebrafish embryos submitted to the endogenous alkaline phosphatase (EAP) assay. Moreover, an increased blood vessel development and an higher level of total hemoglobin content is observed in the CAMs exposed to AUL at 80 μg/egg as compared to control. The proangiogenic effects of AUL in two in vivo models suggest its potential use as a source of new therapeutic agents able to modulate angiogenesis.en
dc.description.affiliationDepartment of Biological Sciences Univ Estadual Paulista
dc.description.affiliationDepartment of Pharmacy University of Salerno, Via Giovanni Paolo II 132
dc.description.affiliationDepartment of Chemical Biological Pharmaceutical and Environmental Sciences University of Messina
dc.description.affiliationUnespDepartment of Biological Sciences Univ Estadual Paulista
dc.format.extent46-54
dc.identifier.citationPharmacologyonline, v. 1, p. 46-54.
dc.identifier.issn1827-8620
dc.identifier.scopus2-s2.0-85019662654
dc.identifier.urihttp://hdl.handle.net/11449/220857
dc.language.isoeng
dc.relation.ispartofPharmacologyonline
dc.sourceScopus
dc.subjectAngiogenesis
dc.subjectAstronium urundeuva
dc.subjectChick chorioallantoic membrane
dc.subjectEndogenous alkaline phosphatase staining
dc.subjectHaemoglobin
dc.subjectZebrafish
dc.titleEffects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)en
dc.typeArtigo

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