Characteristics, Biological Properties and Analytical Methods of Trans-Resveratrol: A Review

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dc.contributor.authorFiod Riccio, Bruno Vincenzo [UNESP]
dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorFerrari, Priscileila Colerato
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.date.accessioned2019-10-04T12:40:26Z
dc.date.available2019-10-04T12:40:26Z
dc.date.issued2019-07-26
dc.description.abstractTrans-resveratrol (TR) is the biological active isomer of resveratrol and the one responsible for therapeutic effects; both molecules are non-flavonoid phenolics of the stilbenes class found mainly in berries and red grapes. TR biological properties lie in modulation of various enzymatic classes. It is a promising candidate to novel drugs due its applications in pharmaceutical and cosmetic industries, such as anticarcinogenic, antidiabetic, antiacne, antioxidant, anti-inflammatory, neuroprotective, and photoprotector agent. It has effects on bone metabolism, gastrointestinal tract, eyes, kidneys, and in obesity treatment as well. Nevertheless, its low solubility in water and other polar solvents may be a hindrance to its therapeutic effects. Various strategies been developed to overcome these issues, such as the drug delivery systems. The present study performed a research about methods to identify TR and RESV in several samples (raw materials, wines, food supplements, drug delivery systems, and blood plasma). Most of the studies tend to analyze TR and RESV by high performance liquid chromatography (HPLC) coupled with different detectors, even so, there are reports of the use of capillary electrophoresis, electron spin resonance, gas chromatography, near-infrared luminescence, UV-Vis spectrophotometer, and vibrational spectrophotometry, for this purpose. Thus, the review evaluates the biological activity of TR and demonstrates the currently used analytical methods for its quantification in different matrices.en
dc.description.affiliationSao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationPonta Grossa State Univ UEPG, Dept Pharmaceut Sci, Ponta Grossa, Parana, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPACD-FCFAr-UNESP (Araraquara, Brazil)
dc.format.extent20
dc.identifierhttp://dx.doi.org/10.1080/10408347.2019.1637242
dc.identifier.citationCritical Reviews In Analytical Chemistry. Philadelphia: Taylor & Francis Inc, 20 p., 2019.
dc.identifier.doi10.1080/10408347.2019.1637242
dc.identifier.issn1040-8347
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/186000
dc.identifier.wosWOS:000479612300001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCritical Reviews In Analytical Chemistry
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAnalytical methods
dc.subjectdrug delivery systems
dc.subjectpharmacological activities
dc.subjectphysicochemical properties
dc.subjectTrans-resveratrol
dc.titleCharacteristics, Biological Properties and Analytical Methods of Trans-Resveratrol: A Reviewen
dc.typeResenha
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-2370-0662[1]
unesp.author.orcid0000-0002-4259-0008[2]
unesp.author.orcid0000-0002-6698-0545[4]

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