Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction

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dc.contributor.authorRocha, Thalita L. A. [UNESP]
dc.contributor.authorBorges, Teubislete F. [UNESP]
dc.contributor.authorRodrigues, Serginara D. [UNESP]
dc.contributor.authorMartins, Laisla Z. [UNESP]
dc.contributor.authorda Silva, Maria L. S. [UNESP]
dc.contributor.authorBonacio, Gisele F.
dc.contributor.authorRizzi, Elen
dc.contributor.authorDias-Junior, Carlos A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUNAERP
dc.date.accessioned2023-07-29T13:53:18Z
dc.date.available2023-07-29T13:53:18Z
dc.date.issued2023-01-01
dc.description.abstractVolatile anesthetics may cause vascular dysfunction; however, underlying effects are unclear. The aim of the present study was to investigate whether sevoflurane and isoflurane affect vascular function, nitric oxide (NO) bioavailability, and biomarkers of oxidative stress and inflammation. Wistar rats were divided into three experimental groups: Not anesthetized (control group) or submitted to anesthesia with isoflurane (Iso group) or sevoflurane (Sevo group). Hemodynamic parameters were monitored during anesthesia, and blood gas values and biochemical determinants were analyzed. Isometric contractions were recorded in aortic rings. Vasoconstriction induced by potassium chloride (KCl) and phenylephrine (Phe) were measured. No differences in hemodynamic parameters and blood gasses variables were observed. Impaired KCl and Phe-induced contractions were observed in endothelium-intact aorta of Sevo compared to Iso and Control groups. Redox imbalance was found in Sevo and Iso groups. Reduced NO bioavailability and increased activity of matrix metalloproteinase 2 (MMP-2) were observed in Sevo, but not in the Iso group. While reduced IL-10 and IL-1β were observed in Sevo, increases in IL-1β in the Iso group were found. Sevoflurane, but not isoflurane, anesthesia impairs vasocontraction, and reduced NO and cytokines and increased MMP-2 activity may be involved in vascular dysfunction after sevoflurane anesthesia.en
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu São Paulo State University UNESP, Sao Paulo
dc.description.affiliationDepartment of Anesthesiology Botucatu Medical School Sao Paulo State University UNESP, Sao Paulo
dc.description.affiliationUnit of Biotechnology University of Ribeirao Preto UNAERP, Sao Paulo
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu São Paulo State University UNESP, Sao Paulo
dc.description.affiliationUnespDepartment of Anesthesiology Botucatu Medical School Sao Paulo State University UNESP, Sao Paulo
dc.identifierhttp://dx.doi.org/10.1111/fcp.12901
dc.identifier.citationFundamental and Clinical Pharmacology.
dc.identifier.doi10.1111/fcp.12901
dc.identifier.issn1472-8206
dc.identifier.issn0767-3981
dc.identifier.scopus2-s2.0-85156222693
dc.identifier.urihttp://hdl.handle.net/11449/248772
dc.language.isoeng
dc.relation.ispartofFundamental and Clinical Pharmacology
dc.sourceScopus
dc.subjectisoflurane
dc.subjectmetalloproteinase
dc.subjectnitric oxide
dc.subjectsevoflurane
dc.subjectvascular function
dc.titleSevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contractionen
dc.typeArtigo
unesp.author.orcid0000-0002-0348-6144[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentAnestesiologia - FMBpt

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