White matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: A critical review of MRI studies

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dc.contributor.authorRadanovic, Marcia
dc.contributor.authorPereira, Fabrício Ramos Silvestre
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.authorAprahamian, Ivan
dc.contributor.authorFerreira, Luiz Kobuti
dc.contributor.authorForlenza, Orestes Vicente
dc.contributor.authorBusatto, Geraldo F.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:04Z
dc.date.available2014-05-27T11:29:04Z
dc.date.issued2013-05-01
dc.description.abstractIn this article, the authors aim to present a critical review of recent MRI studies addressing white matter (WM) abnormalities in Alzheimer's disease (AD) and mild cognitive impairment (MCI), by searching PubMed and reviewing MRI studies evaluating subjects with AD or MCI using WM volumetric methods, diffusion tensor imaging and assessment of WM hyperintensities. Studies have found that, compared with healthy controls, AD and MCI samples display WM volumetric reductions and diffusion tensor imaging findings suggestive of reduced WM integrity. These changes affect complex networks relevant to episodic memory and other cognitive processes, including fiber connections that directly link medial temporal structures and the corpus callosum. Abnormalities in cortico-cortical and cortico-subcortical WM interconnections are associated with an increased risk of progression from MCI to dementia. It can be concluded that WM abnormalities are detectable in early stages of AD and MCI. Degeneration of WM networks causes disconnection among neural cells and the degree of such changes is related to cognitive decline. © 2013 2013 Expert Reviews Ltd.en
dc.description.affiliationLaboratory of Neurosciences Institute of Psychiatry University of São Paulo, São Paulo
dc.description.affiliationCenter for Interdisciplinary Research on Applied Neurosciences (NAPNA) University of São Paulo, São Paulo
dc.description.affiliationLaboratory of Psychiatric Neuroimaging Faculty of Medicine University of São Paulo, São Paulo
dc.description.affiliationBiosciences Institute Universidade Estadual Paulista Campus of Rio Claro, São Paulo
dc.description.affiliationUnespBiosciences Institute Universidade Estadual Paulista Campus of Rio Claro, São Paulo
dc.format.extent483-493
dc.identifierhttp://dx.doi.org/10.1586/ern.13.45
dc.identifier.citationExpert Review of Neurotherapeutics, v. 13, n. 5, p. 483-493, 2013.
dc.identifier.doi10.1586/ern.13.45
dc.identifier.issn1473-7175
dc.identifier.issn1744-8360
dc.identifier.lattes7964386240653380
dc.identifier.scopus2-s2.0-84876936083
dc.identifier.urihttp://hdl.handle.net/11449/75278
dc.identifier.wosWOS:000319372800010
dc.language.isoeng
dc.relation.ispartofExpert Review of Neurotherapeutics
dc.relation.ispartofjcr3.692
dc.relation.ispartofsjr1,006
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectbrain connections
dc.subjectdiffusion tensor imaging
dc.subjectmild cognitive impairment
dc.subjectvoxel-based morphometry
dc.subjectwhite matter
dc.subjectAlzheimer disease
dc.subjectcognitive defect
dc.subjectcorpus callosum
dc.subjectdementia
dc.subjecthuman
dc.subjectMedline
dc.subjectneuroimaging
dc.subjectneuropathology
dc.subjectneuropsychiatry
dc.subjectnuclear magnetic resonance imaging
dc.subjectreview
dc.subjectvolumetry
dc.titleWhite matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: A critical review of MRI studiesen
dc.typeResenha
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes7964386240653380
unesp.author.orcid0000-0002-3256-6397[1]
unesp.author.orcid0000-0003-4762-047X[5]
unesp.author.orcid0000-0003-3317-8756[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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