Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing

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dc.contributor.authorGoncalves Dias, Fernanda Gosuen
dc.contributor.authorPereira, Lucas de Freitas
dc.contributor.authorFurtado, Ricardo Andrade
dc.contributor.authorMagalhaes, Georgia Mode
dc.contributor.authorMiguel, Marina Pacheco
dc.contributor.authorGosuen Goncalves Dias, Luis Gustavo [UNESP]
dc.contributor.authorJorge, Adriana Torrecilhas
dc.contributor.authorHonsho, Cristiane dos Santos
dc.contributor.authorAmbrosio, Sergio Ricardo
dc.contributor.authorBastos, Jairo Kenupp
dc.contributor.authorCarrijo, Micaela Silva
dc.contributor.authorTavares, Denise Crispim
dc.contributor.institutionUniv Franca
dc.contributor.institutionInst Fed Minas Gerais
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2021-06-25T11:51:13Z
dc.date.available2021-06-25T11:51:13Z
dc.date.issued2021-03-01
dc.description.abstractObjective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic eiythrocytes to total eiythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.en
dc.description.affiliationUniv Franca, Dept Vet Med, Franca, SP, Brazil
dc.description.affiliationInst Fed Minas Gerais, Dept Vet Med, Muzambinho, MG, Brazil
dc.description.affiliationUniv Fed Goias, Dept Vet Med, Goiania, Go, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Vet Med, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Franca, Dept Sci, Franca, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Pharm, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Vet Med, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2011/13630-7
dc.format.extent120-133
dc.identifier.citationAvicenna Journal Of Phytomedicine. Mashhad: Mashhad Univ Med Sciences, v. 11, n. 2, p. 120-133, 2021.
dc.identifier.issn2228-7930
dc.identifier.urihttp://hdl.handle.net/11449/209197
dc.identifier.wosWOS:000617063800003
dc.language.isoeng
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofAvicenna Journal Of Phytomedicine
dc.sourceWeb of Science
dc.subjectCutaneous wound healing
dc.subjectCopaifera duckei Dwyer oleoresin
dc.subjectToxicity
dc.titleTopical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healingen
dc.typeArtigo
dcterms.rightsHolderMashhad Univ Med Sciences

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