An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:35:21Z
dc.date.available2018-12-11T17:35:21Z
dc.date.issued2018-05-01
dc.description.abstractOwing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests.en
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 13/03746-3
dc.description.sponsorshipIdFAPESP: 15/05394-2
dc.format.extent129-143
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2017.12.022
dc.identifier.citationMaterials Science and Engineering C, v. 86, p. 129-143.
dc.identifier.doi10.1016/j.msec.2017.12.022
dc.identifier.file2-s2.0-85040004712.pdf
dc.identifier.issn0928-4931
dc.identifier.lattes1427125996716282
dc.identifier.scopus2-s2.0-85040004712
dc.identifier.urihttp://hdl.handle.net/11449/179480
dc.language.isoeng
dc.relation.ispartofMaterials Science and Engineering C
dc.relation.ispartofsjr1,110
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBuccal route
dc.subjectDrug delivery
dc.subjectMucoadhesion
dc.subjectPharmacodynamics
dc.subjectPharmacokinetics
dc.subjectPolymers
dc.titleAn overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluationen
dc.typeResenha
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-4259-0008[1]
unesp.author.orcid0000-0002-6698-0545[2]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas