Antibacterial activity of alkyl gallates against Xanthomonas citri subsp. citri

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dc.contributor.authorSilva, I. C. [UNESP]
dc.contributor.authorRegasini, L. O. [UNESP]
dc.contributor.authorPetrãnio, M. S. [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorBelasque, Jr.
dc.contributor.authorSacramento, L. V S [UNESP]
dc.contributor.authorFerreira, H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFundecitrus
dc.date.accessioned2014-05-27T11:27:30Z
dc.date.available2014-05-27T11:27:30Z
dc.date.issued2013-01-01
dc.description.abstractThe plant-pathogenic bacterium Xanthomonas citri subsp. citri is the causal agent of Asiatic citrus canker, a seriousdisease that affects all the cultivars of citrus in subtropical citrus-producing areas worldwide. There is no curative treatment for citrus canker; thus, the eradication of infected plants constitutes the only effective control of the spread ofX. citri subsp. citri. Since the eradication program in the state of São Paulo, Brazil, is under threat, there is a clear risk of X. citri subsp. citri becoming endemic in the main orange-producing area in the world. Here we evaluated the potential use of alkyl gallates to prevent X. citri subsp. citri growth. These esters displayed a potent anti-X. citri subsp. citri activity similar to that of kanamycin (positive control), as evaluated by the resazurin microtiter assay (REMA). Thetreatment of X. citri subsp. citri cells with these compounds induced altered cell morphology, and investigations of the possible intracellular targets using X. citri subsp. citri strains labeled for the septum and centromere pointed to a commontarget involved in chromosome segregation and cell division. Finally, the artificial inoculation of citrus with X. citri subsp. citri cells pretreated with alkyl gallates showed that the bacterium loses the ability to colonize its host, which indicates the potential of these esters to protect citrus plants against X. citri subsp. citri infection. © 2013, American Society for Microbiology.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas (FCF) Departamento de Ciências Biológicas Universidade Estadual Paulista (UNESP), Araraquara, Sao Paulo
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química UNESP, Araraquara, Sao Paulo
dc.description.affiliationDepartamento Científico Fundecitrus, Araraquara, Sao Paulo
dc.description.affiliationDepartamento de Princípios Ativos Naturais e Toxicologia FCF UNESP, Araraquara, Sao Paulo
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas (FCF) Departamento de Ciências Biológicas Universidade Estadual Paulista (UNESP), Araraquara, Sao Paulo
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química UNESP, Araraquara, Sao Paulo
dc.description.affiliationUnespDepartamento de Princípios Ativos Naturais e Toxicologia FCF UNESP, Araraquara, Sao Paulo
dc.format.extent85-94
dc.identifierhttp://dx.doi.org/10.1128/JB.01442-12
dc.identifier.citationJournal of Bacteriology, v. 195, n. 1, p. 85-94, 2013.
dc.identifier.doi10.1128/JB.01442-12
dc.identifier.file2-s2.0-84872042524.pdf
dc.identifier.issn0021-9193
dc.identifier.issn1098-5530
dc.identifier.lattes4702004904231248
dc.identifier.lattes4484083685251673
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.scopus2-s2.0-84872042524
dc.identifier.urihttp://hdl.handle.net/11449/74236
dc.identifier.wosWOS:000316959000012
dc.language.isoeng
dc.relation.ispartofJournal of Bacteriology
dc.relation.ispartofjcr3.219
dc.relation.ispartofsjr1,885
dc.relation.ispartofsjr1,885
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantiinfective agent
dc.subjectgallic acid alkyl ester
dc.subjectgallic acid derivative
dc.subjectkanamycin
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectbacterial cell
dc.subjectbacterial colonization
dc.subjectbacterial growth
dc.subjectcell division
dc.subjectcell structure
dc.subjectcentromere
dc.subjectchromosome segregation
dc.subjectcontrolled study
dc.subjectdrug potency
dc.subjectdrug targeting
dc.subjectgrowth inhibition
dc.subjectinoculation
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectXanthomonas citri
dc.subjectAnti-Bacterial Agents
dc.subjectCitrus
dc.subjectGallic Acid
dc.subjectMolecular Structure
dc.subjectPlant Diseases
dc.subjectPlant Leaves
dc.subjectXanthomonas
dc.subjectBacteria (microorganisms)
dc.titleAntibacterial activity of alkyl gallates against Xanthomonas citri subsp. citrien
dc.typeArtigo
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
unesp.author.lattes4702004904231248[4]
unesp.author.lattes4484083685251673
unesp.author.orcid0000-0002-1516-7765[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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