Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential

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dc.contributor.authorMarena, Gabriel Davi
dc.contributor.authorGirotto, Luiza
dc.contributor.authorSaldanha, Luiz Leonardo [UNESP]
dc.contributor.authorRamos, Matheus Aparecido Dos Santos [UNESP]
dc.contributor.authorDe Grandis, Rone Aparecido [UNESP]
dc.contributor.authorDa Silva, Patrícia Bento [UNESP]
dc.contributor.authorDokkedal, Anne Lígia [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorBauab, Tais Maria [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorTrovatti, Eliane
dc.contributor.authorLustri, Wilton Rogério
dc.contributor.authorResende, Flávia Ap.
dc.contributor.institutionUniversity of Araraquara (UNIARA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNanobiotechnology Laboratory
dc.contributor.institutionUNIARA Carlos Gomes 1338
dc.date.accessioned2021-06-25T10:50:48Z
dc.date.available2021-06-25T10:50:48Z
dc.date.issued2020-01-01
dc.description.abstractMyrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M. bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M. bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M. bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M. bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp.en
dc.description.affiliationUniversity of Araraquara (UNIARA) Department of Biological Sciences and Health
dc.description.affiliationSão Paulo State University (UNESP) Department of Biological Sciences Faculty of Science
dc.description.affiliationSão Paulo State University (UNESP) Department of Biological Sciences School of Pharmaceutical Sciences, Campus Araraquara
dc.description.affiliationSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Campus Araraquara
dc.description.affiliationUniversity of Brasilia Nanobiotechnology Laboratory Department of Genetics and Morphology
dc.description.affiliationUniversity of Araraquara Department of Biological Sciences and Health UNIARA Carlos Gomes 1338, Rua Carlos Gomes, 1217
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Biological Sciences Faculty of Science
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Biological Sciences School of Pharmaceutical Sciences, Campus Araraquara
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Campus Araraquara
dc.identifierhttp://dx.doi.org/10.1055/a-1323-3622
dc.identifier.citationPlanta Medica.
dc.identifier.doi10.1055/a-1323-3622
dc.identifier.issn1439-0221
dc.identifier.issn0032-0943
dc.identifier.scopus2-s2.0-85100215672
dc.identifier.urihttp://hdl.handle.net/11449/207215
dc.language.isoeng
dc.relation.ispartofPlanta Medica
dc.sourceScopus
dc.subjectantifungal
dc.subjectbiopharmaceuticals
dc.subjectbiotechnology
dc.subjectmutagenicity
dc.subjectMyrcia bella
dc.subjectMyrtaceae
dc.subjectnanotechnology
dc.titleHydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potentialen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas