In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide

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dc.contributor.authorDi Filippo, Leonardo Delello [UNESP]
dc.contributor.authorDuarte, Jonatas Lobato [UNESP]
dc.contributor.authorRoque-Borda, Cesar Augusto [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorMeneguin, Andreia Bagliotti [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorMelero, Ana
dc.contributor.authorGuillot, Antonio José
dc.contributor.authorSpagnol, Caroline Magnani [UNESP]
dc.contributor.authorCorrea, Marcos Antônio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Valencia
dc.date.accessioned2023-03-02T11:50:27Z
dc.date.available2023-03-02T11:50:27Z
dc.date.issued2022-07-01
dc.description.abstractVitamins are widely found in nature, for example, in plants and fruits. Ascorbic acid and nicotinamide are examples of these compounds that have potent antioxidant properties, besides stimulating collagen production and depigmenting properties that protect the skin from premature aging. To overcome the skin barrier and reduce the instability of antioxidant compounds, alternative systems have been developed to facilitate the delivery of antioxidants, making them efficiently available to the tissue for an extended time without causing damage or toxicity. The objective of this study was to obtain chitosan biodegradable microparticles containing ascorbic acid and nicotinamide for topical delivery. The microparticles were obtained by spray drying and characterized chemically by means of scanning electron microscopy, infrared spectroscopy, X-ray diffraction, and differential exploratory calorimetry. The drugs were successfully encapsulated and the microparticles showed positive zeta potential. In vitro release assays showed a sustained release profile. The evaluation of ex vivo skin permeation and retention demonstrated low permeation and adequate retention of the compounds in the epidermis/dermis, suggesting the efficient delivery from the obtained microparticles. Antibacterial assays have shown that microparticles can inhibit the growth of microorganisms in a time- and dose-dependent manner, corroborating their use in cosmetic products for application on the skin.en
dc.description.affiliationSchool of Pharmaceutical Sciences Sao Paulo State University “Julio de Mesquita Filho”, SP
dc.description.affiliationPharmaceutical Technology and Parasitology Department of Pharmacy University of Valencia
dc.description.affiliationUnespSchool of Pharmaceutical Sciences Sao Paulo State University “Julio de Mesquita Filho”, SP
dc.description.sponsorshipUniversitat de València
dc.description.sponsorshipIdUniversitat de València: UV-19-INV-AE19
dc.identifierhttp://dx.doi.org/10.3390/life12071049
dc.identifier.citationLife, v. 12, n. 7, 2022.
dc.identifier.doi10.3390/life12071049
dc.identifier.issn2075-1729
dc.identifier.scopus2-s2.0-85136550866
dc.identifier.urihttp://hdl.handle.net/11449/242193
dc.language.isoeng
dc.relation.ispartofLife
dc.sourceScopus
dc.subjectantioxidants
dc.subjectpolymeric microparticles
dc.subjectskin delivery
dc.subjectspray drying
dc.titleIn Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamideen
dc.typeArtigo
unesp.author.orcid0000-0001-6365-8756[1]
unesp.author.orcid0000-0002-9262-0383[3]
unesp.author.orcid0000-0002-6698-0545[6]
unesp.author.orcid0000-0003-0126-414X[7]
unesp.author.orcid0000-0001-8012-326X[8]
unesp.author.orcid0000-0002-1329-8251[9]
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas