Effect of oral vanadyl sulfate treatment on serum enzymes and lipids of streptozotocin-diabetic young rats

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dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.authorMagnani, MRT
dc.contributor.authorKettelhut, I. C.
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:34Z
dc.date.available2014-05-20T13:24:34Z
dc.date.issued1999-08-01
dc.description.abstractIn this work we investigate the possible toxicity of vanadyl sulfate (VOSO4), a compound capable of reducing hyperglycemia, on the following serum enzymes of diabetic young rats: alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LD) and creatine kinase (CK), as well as its effects on serum lipids. We find that at a concentration of 1 mg/mL VOSO4 has no toxic effect on the liver and muscles of diabetics young rats. These findings suggest that VOSO4 may be an alternative to insulin in the near future, due to its low cost, low toxicity and ready availability.en
dc.description.affiliationUNESP, Fac Pharmaceut Sci Araraquara, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Biochem, BR-05508 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Pharmaceut Sci Araraquara, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.format.extent157-161
dc.identifierhttp://dx.doi.org/10.1023/A:1006917007148
dc.identifier.citationMolecular and Cellular Biochemistry. Dordrecht: Kluwer Academic Publ, v. 198, n. 1-2, p. 157-161, 1999.
dc.identifier.doi10.1023/A:1006917007148
dc.identifier.issn0300-8177
dc.identifier.urihttp://hdl.handle.net/11449/7661
dc.identifier.wosWOS:000082527300020
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofMolecular and Cellular Biochemistry
dc.relation.ispartofjcr2.561
dc.relation.ispartofsjr1,003
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectvanadyl sulfatept
dc.subjecthyperglycemiapt
dc.subjectdiabetes mellituspt
dc.subjectinsulinpt
dc.subjectserum enzymespt
dc.titleEffect of oral vanadyl sulfate treatment on serum enzymes and lipids of streptozotocin-diabetic young ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic Publ
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas