Biomimetic Growth of Metal–Organic Frameworks for the Stabilization of the Dentin Matrix and Control of Collagenolysis

dc.contributor.authorBim-Junior, Odair [UNESP]
dc.contributor.authorAlania, Yvette
dc.contributor.authorTabatabaei, Fahimeh Sadat
dc.contributor.authorFrem, Regina [UNESP]
dc.contributor.authorBedran-Russo, Ana K.
dc.contributor.authorLisboa-Filho, Paulo N. [UNESP]
dc.contributor.institutionMarquette University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:39:18Z
dc.date.available2022-04-29T08:39:18Z
dc.date.issued2022-02-01
dc.description.abstractThe dentin matrix is a collagenous scaffold structurally involved in anchoring resin-based materials to the tooth. Time-dependent degradation of this scaffold at the resin–dentin interface remains a core problem in adhesive dentistry, limiting the service life of dental fillings. This study explored the use of emergent materials termed metal–organic frameworks (MOFs)─formed by the self-assembly of metal ions and organic building blocks─to safeguard the collagen integrity in the functional dentin matrix. We demonstrate that collagen fibrils (from demineralized human dentin) can induce the biomimetic growth of MOF crystals as protective coatings to strengthen and stabilize the fibrils. Zeolitic imidazolate framework-8 (ZIF-8), a zinc-based microporous MOF, was used to fabricate the MOF composites via a “one-pot” reaction in water. The ZIF-modified dentin matrix presented superior mechanical strength and resistance to proteolysis, which can positively affect the longevity of collagen as an anchoring substrate. This work identifies a potential biomedical application of biomimetically synthesized MOFs in repairing dental tissues critical to restorative therapies.en
dc.description.affiliationDepartment of General Dental Sciences School of Dentistry Marquette University
dc.description.affiliationDepartment of Physics School of Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Inorganic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Physics School of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Inorganic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)
dc.format.extent1600-1610
dc.identifierhttp://dx.doi.org/10.1021/acs.langmuir.1c03073
dc.identifier.citationLangmuir, v. 38, n. 4, p. 1600-1610, 2022.
dc.identifier.doi10.1021/acs.langmuir.1c03073
dc.identifier.issn1520-5827
dc.identifier.issn0743-7463
dc.identifier.scopus2-s2.0-85123859404
dc.identifier.urihttp://hdl.handle.net/11449/230316
dc.language.isoeng
dc.relation.ispartofLangmuir
dc.sourceScopus
dc.titleBiomimetic Growth of Metal–Organic Frameworks for the Stabilization of the Dentin Matrix and Control of Collagenolysisen
dc.typeArtigo
unesp.author.orcid0000-0001-9938-9500 0000-0001-9938-9500[1]
unesp.author.orcid0000-0001-8666-389X[2]
unesp.author.orcid0000-0003-1574-681X[4]
unesp.author.orcid0000-0002-3670-9519[5]
unesp.author.orcid0000-0002-7734-4069[6]

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