Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

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dc.contributor.authorRodrigues, Danilo F. [UNESP]
dc.contributor.authorManiscalco, David A.
dc.contributor.authorSilva, Flavia A. J. [UNESP]
dc.contributor.authorChiari, Bruna G. [UNESP]
dc.contributor.authorCastelli, Maria V.
dc.contributor.authorIsaac, Vera L. B. [UNESP]
dc.contributor.authorCicarelli, Regina M. B. [UNESP]
dc.contributor.authorLopez, Silvia N.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Nacl Rosario
dc.date.accessioned2018-11-26T17:21:04Z
dc.date.available2018-11-26T17:21:04Z
dc.date.issued2017-02-01
dc.description.abstractThe trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 mu M, IC50 = 34.7 mu M benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 mu M, IC50 = 6.4 mu M pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 mu M). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Biol Sci, Araraquara, Brazil
dc.description.affiliationSao Paulo State Univ, Inst Chem, Araraquara, Brazil
dc.description.affiliationUniv Nacl Rosario, CONICET, Farmacognosia, Fac Ciencias Bioquim & Farmaceut, Rosario, Argentina
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Medicaments, Araraquara, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Biol Sci, Araraquara, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Chem, Araraquara, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Medicaments, Araraquara, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNacional de Investigaciones Cientificas y Tecnicas de Argentina
dc.description.sponsorshipFONCyT
dc.description.sponsorshipUniversidad Nacional de Rosario (UNR)
dc.description.sponsorshipIdNacional de Investigaciones Cientificas y Tecnicas de Argentina: PIP 112-201201-00695 CONICET
dc.description.sponsorshipIdFONCyT: PICT E 2014-0175
dc.description.sponsorshipIdUniversidad Nacional de Rosario (UNR): BIO442
dc.format.extent239-244
dc.identifierhttp://dx.doi.org/10.1055/s-0042-112031
dc.identifier.citationPlanta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 83, n. 3-4, p. 239-244, 2017.
dc.identifier.doi10.1055/s-0042-112031
dc.identifier.issn0032-0943
dc.identifier.urihttp://hdl.handle.net/11449/162599
dc.identifier.wosWOS:000397029700007
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofPlanta Medica
dc.relation.ispartofsjr0,581
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTrypanosoma cruzi
dc.subjectTrypanosoma brucei
dc.subjectflavokawin B
dc.subjectchalcone
dc.subjecttrans-splicing
dc.subjectPolygonum ferrugineum
dc.subjectPolygonaceae
dc.titleTrypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedden
dc.typeArtigo
dcterms.rightsHolderGeorg Thieme Verlag Kg
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas