Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease

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dc.contributor.authorVitório, Rodrigo [UNESP]
dc.contributor.authorLirani-Silva, Ellen
dc.contributor.authorOrcioli-Silva, Diego [UNESP]
dc.contributor.authorBeretta, Victor Spiandor [UNESP]
dc.contributor.authorOliveira, Anderson Souza
dc.contributor.authorGobbi, Lilian Teresa Bucken [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionNorthumbria University
dc.contributor.institutionNewcastle University
dc.contributor.institutionAalborg University
dc.date.accessioned2023-07-29T16:14:56Z
dc.date.available2023-07-29T16:14:56Z
dc.date.issued2023-05-01
dc.description.abstractThe neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy individuals. Fifteen people with PD and fourteen older adults walked overground in two conditions: usual walking and obstacle crossing. Scalp electroencephalography (EEG) was recorded using a mobile 64-channel EEG system. Independent components were clustered using a k-means clustering algorithm. Outcome measures included absolute power in several frequency bands and alpha/beta ratio. During the usual walk, people with PD presented a greater alpha/beta ratio in the left sensorimotor cortex than healthy individuals. While approaching obstacles, both groups reduced alpha and beta power in the premotor and right sensorimotor cortices (balance demand) and increased gamma power in the primary visual cortex (visual demand). Only people with PD reduced alpha power and alpha/beta ratio in the left sensorimotor cortex when approaching obstacles. These findings suggest that PD affects the cortical control of usual walking, leading to a greater proportion of low-frequency (alpha) neuronal firing in the sensorimotor cortex. Moreover, the planning for obstacle avoidance changes the electrocortical dynamics associated with increased balance and visual demands. People with PD rely on increased sensorimotor integration to modulate locomotion.en
dc.description.affiliationInstitute of Biosciences Sao Paulo State University (UNESP)
dc.description.affiliationGraduate Program in Movement Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Sport Exercise and Rehabilitation Northumbria University
dc.description.affiliationTranslational and Clinical Research Institute Faculty of Medical Sciences Newcastle University
dc.description.affiliationSchool of Technology and Sciences Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Materials and Production Aalborg University
dc.description.affiliationUnespInstitute of Biosciences Sao Paulo State University (UNESP)
dc.description.affiliationUnespGraduate Program in Movement Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Technology and Sciences Sao Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/s23104866
dc.identifier.citationSensors, v. 23, n. 10, 2023.
dc.identifier.doi10.3390/s23104866
dc.identifier.issn1424-8220
dc.identifier.scopus2-s2.0-85160394791
dc.identifier.urihttp://hdl.handle.net/11449/249995
dc.language.isoeng
dc.relation.ispartofSensors
dc.sourceScopus
dc.subjectEEG
dc.subjectgait
dc.subjectlocomotion
dc.subjectmovement disorders
dc.titleElectrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Diseaseen
dc.typeArtigo
unesp.author.orcid0000-0001-7128-9452[1]
unesp.author.orcid0000-0002-7658-6883[2]
unesp.author.orcid0000-0002-4640-7733[4]
unesp.author.orcid0000-0003-2186-8100[5]

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