Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation

dc.contributor.authorCazedey, Edith Cristina Laignier [UNESP]
dc.contributor.authorCarvalho, Flávia Chiva [UNESP]
dc.contributor.authorFiorentino, Flávia Angélica Másquio [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T21:00:54Z
dc.date.available2022-04-28T21:00:54Z
dc.date.issued2009-10-01
dc.description.abstractTests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. Protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. International organizations, such as the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Institute of Health (NIH), the Organization for Economic Co-operation and Development (OECD), that regulate and develop new alternative animal models, have indicated the running of preliminary assays and execution of sequential tests, which consider physical-chemical properties and data of in vitro assays, before performing in vivo studies. Towards this background, the objective of the present article was to select promising alternative methods such as Corrositex®, BCOP and HET-CAM, intended to refine or replace the use of animals and reduce their suffering.en
dc.description.affiliationDepartment of Drugs and Medicines Faculty of Pharmaceutical Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, Rodovia Araraquara-Jau, km 1, 14801-902 - Araraquara - SP
dc.description.affiliationUnespDepartment of Drugs and Medicines Faculty of Pharmaceutical Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, Rodovia Araraquara-Jau, km 1, 14801-902 - Araraquara - SP
dc.format.extent759-766
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502009000400021
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 45, n. 4, p. 759-766, 2009.
dc.identifier.doi10.1590/S1984-82502009000400021
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-77950660726
dc.identifier.urihttp://hdl.handle.net/11449/225824
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.sourceScopus
dc.subjectAnimal experimentation/alternative methods in vitro
dc.subjectBCOP/in vitro method/experiments
dc.subjectCorrositex®/in vitro method/experiments
dc.subjectExperiments/in vitro methods
dc.subjectHET-CAM/in vitro method/experiments
dc.titleCorrositex®, BCOP and HET-CAM as alternative methods to animal experimentationen
dc.typeArtigo

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