Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study

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dc.contributor.authorCosin Shindo, João Vitor Tadashi
dc.contributor.authorRodokas, José Eduardo Petit [UNESP]
dc.contributor.authordos Santos Sousa, Guilherme
dc.contributor.authorMaciel, Fabio Oliveira
dc.contributor.authorCouto, Maira Cristina Rondina
dc.contributor.authorMatsumoto, Mariza Akemi [UNESP]
dc.contributor.authorSangalette, Beatriz
dc.contributor.authorGerman, Iris Jasmin Santos
dc.contributor.authorPomini, Karina Torres
dc.contributor.authorAndreo, Jesus Carlos
dc.contributor.authorShinohara, André Luís
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUFAM
dc.date.accessioned2022-04-28T19:52:03Z
dc.date.available2022-04-28T19:52:03Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: neuromuscular electrostimulation (NMES) is a promising strategy for recovering muscle mass and function, including in elderly patients suffering from sarcopenia. We developed a vest with coupled electrodes to introduce electrostimulation throughout the body of young mice and verify the morphological changes in the scapular and pelvic region muscles. Material and Methods: a vest based on the semi-flexible resin was developed with the electrodes already attached, printed by 3D printing with connectivity to the Neurodyn III electrostimulation device (Ibramed ®). Based on this, six 14-weeks old C57BL/6 WT mice were used to conduct this pilot study. Results: After four weeks, we found that using the vest with the coupled electrodes was able to generate an increase in CSA in the gluteus and trapezius muscle compared to control mice (p<0.05). The gluteus of the experimental group (EG) hypertrophied 15% more than the control group (CG). As occurred in the gluteus, in the trapezius muscle, the CSA was 37% higher in EG than in CG. Conclusions: we conclude that this model of NMES in mice leaded to morphological changes in scapular and pelvic region muscles. For future work, we intend to include molecular and functional analyzes to evaluate if our model can reproduce the same functional effects reported in studies and afterward apply this model to elderly animals.en
dc.description.affiliationDepartment of Anatomy Bauru School of Dentistry University of São Paulo FOB-USP, SP
dc.description.affiliationSão Paulo State University (UNESP), SP
dc.description.affiliationDepartment of Bioceramics Federal Univesity of São Paulo (UNIFESP), SP
dc.description.affiliationFederal University of Amazonas UFAM, AM
dc.description.affiliationDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP
dc.description.affiliationUnespSão Paulo State University (UNESP), SP
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP
dc.format.extent398-403
dc.identifierhttp://dx.doi.org/10.51929/jms.38.69.2021
dc.identifier.citationJournal of Morphological Sciences, v. 38, p. 398-403.
dc.identifier.doi10.51929/jms.38.69.2021
dc.identifier.issn2177-0298
dc.identifier.scopus2-s2.0-85126560996
dc.identifier.urihttp://hdl.handle.net/11449/223672
dc.language.isoeng
dc.relation.ispartofJournal of Morphological Sciences
dc.sourceScopus
dc.subjectElectrostimulation
dc.subjectHypertrophy
dc.subjectSarcopenia
dc.subjectSkeletal Muscle
dc.titleNeuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Studyen
dc.typeArtigo
unesp.author.orcid0000-0002-0230-5962[1]
unesp.author.orcid0000-0003-2683-9982[2]
unesp.author.orcid0000-0001-6174-2794[3]
unesp.author.orcid0000-0001-5389-0105[6]
unesp.author.orcid0000-0001-7030-8885[7]
unesp.author.orcid0000-0002-7624-7689[8]
unesp.author.orcid0000-0003-2858-4717[9]
unesp.author.orcid0000-0001-7227-1908[10]
unesp.author.orcid0000-0003-4444-3949[11]

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