Anticlastogenic activity of aqueous extract of Agaricus blazei in drug-metabolizing cells (HTCs) during cell cycle

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dc.contributor.authorMatuo, R.
dc.contributor.authorOliveira, R. J.
dc.contributor.authorSilva, A.F.
dc.contributor.authorMantovani, M. S.
dc.contributor.authorRibeiro, L. R.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:24:36Z
dc.date.available2014-05-20T15:24:36Z
dc.date.issued2007-03-01
dc.description.abstractThe mushroom Agaricus blazei has been extensively investigated because of evidence of its antimutagenic, antitumor, and anticarcinogenic activities. This study investigated the clastogenic and/or anticlastogenic activity of aqueous extract of Agaricus blazei (10% w/v) in drug-metabolizing rat hepatoma tissue cells (HTCs), with continuous treatment and treatment during different phases of the cell cycle. DNA damage was induced utilizing two directacting agents-methyl methane sulfonate and ethyl methane sulfonate-and two indirect-acting agents-2-aminoanthracene and cyclophosphamide. The aqueous extract of A. blazei with either continuous treatment or treatment during different phases of the cell cycle showed clastogenic activity. The results with continuous treatment showed that A. blazei does not protect against DNA damage-inducing agents that are direct acting. Meanwhile, when combined with indirect-acting agents, a protective effect was demonstrated. A protective effect was also found during different phases of the cell cycle when cells were treated with indirect-acting agents. The protective effects against indirect-acting agents (continuous treatment and during the different phases of the cell cycle) suggest that A. blazei may provide some health benefits to the public when used as a functional food.en
dc.description.affiliationUniv Estadual Londrina, Dept Biol Geral, CCB, BR-86051990 Londrina, Parana, Brazil
dc.description.affiliationUNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, BR-18618000 Botucatu, SP, Brazil
dc.format.extent147-152
dc.identifierhttp://dx.doi.org/10.1080/15376510600899456
dc.identifier.citationToxicology Mechanisms and Methods. Philadelphia: Taylor & Francis Inc., v. 17, n. 3, p. 147-152, 2007.
dc.identifier.doi10.1080/15376510600899456
dc.identifier.issn1537-6524
dc.identifier.urihttp://hdl.handle.net/11449/35179
dc.identifier.wosWOS:000245987500003
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofToxicology Mechanisms and Methods
dc.relation.ispartofsjr0,562
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgaricus blazeipt
dc.subjectanticlastogenicitypt
dc.subjectHTCpt
dc.subjectdirect and indirect-acting agentspt
dc.titleAnticlastogenic activity of aqueous extract of Agaricus blazei in drug-metabolizing cells (HTCs) during cell cycleen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.orcid0000-0001-5268-6508[4]

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