Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia

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dc.contributor.authorGomes, Liana Silva
dc.contributor.authorda Silva Lima, Danilo
dc.contributor.authorCosta, Janaína Ribeiro
dc.contributor.authorNaves, Jane Sousa
dc.contributor.authorMarques, Mara Rúbia
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.authorGhedini, Paulo César
dc.contributor.authorBiancardi, Manoel Francisco
dc.contributor.authorAlcantara dos Santos, Fernanda Cristina
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:39:50Z
dc.date.available2023-07-29T13:39:50Z
dc.date.issued2023-05-01
dc.description.abstractSeveral pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging.en
dc.description.affiliationLaboratory of Microscopy Applied to Reproduction Department of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás, Goiás
dc.description.affiliationLaboratory of Microscopy and Microanalysis Department of Biology University Estadual Paulista – UNESP, São Paulo
dc.description.affiliationLaboratory of Molecular and Biochemistry Pharmacology Department of Pharmacology Institute of Biological Sciences Federal University of Goiás, Goiás
dc.description.affiliationUnespLaboratory of Microscopy and Microanalysis Department of Biology University Estadual Paulista – UNESP, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Goiás
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFundação de Amparo à Pesquisa do Estado de Goiás: 02/2018
dc.description.sponsorshipIdCNPq: 206895/2021-8
dc.description.sponsorshipIdCAPES: Finance code 001
dc.format.extent990-1003
dc.identifierhttp://dx.doi.org/10.1002/cbin.11995
dc.identifier.citationCell Biology International, v. 47, n. 5, p. 990-1003, 2023.
dc.identifier.doi10.1002/cbin.11995
dc.identifier.issn1095-8355
dc.identifier.issn1065-6995
dc.identifier.scopus2-s2.0-85147203468
dc.identifier.urihttp://hdl.handle.net/11449/248292
dc.language.isoeng
dc.relation.ispartofCell Biology International
dc.sourceScopus
dc.subjectandrogens
dc.subjectendocrine disruptors
dc.subjectestrogens
dc.subjectfemale prostate
dc.subjectmetals
dc.subjectventral prostate
dc.titleNeonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasiaen
dc.typeArtigo
unesp.author.orcid0000-0002-0970-4288[6]
unesp.author.orcid0000-0002-4476-6046[9]

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Botucatu - CME - Centro de Microscopia Eletrônica