Primary Pulmonary Choriocarcinoma After Human Chorionic Gonadotropin Normalization Following Hydatidiform Mole A Report of Two Cases

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dc.contributor.authorMaestá, Izildinha [UNESP]
dc.contributor.authorLeite, Fabio Vicente
dc.contributor.authorMichelin, Odair Carlito
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:16Z
dc.date.available2014-05-20T13:35:16Z
dc.date.issued2010-07-01
dc.description.abstractBACKGROUND: Primary pulmonary choriocarcinoma (PPC) is rare and frequently leads to death.CASES: Two young patients presented with previous molar pregnancy and spontaneous serum human chorionic gonadotropin (hCG) normalization. Patient 1 was referred to our center after partial response to chemotherapy. Pulmonary lobectomy was performed, and hCG rapidly declined. During further chemotherapy, liver metastasis was detected by positron emission tomography. Right hepatectomy was performed, and hCG declined for 28 days, but increased again despite chemotherapy. This patient died from hepatic failure 3 years after diagnosis. Patient 2 presented with persistently high hCG, though the affected organ was not identified. Chemotherapy was unsuccessful. Patient reevaluation showed an isolated pulmonary mass. Pulmonary lobectomy was performed; 2 weeks later, hCG was normal and consolidation with 2 cycles of chemotherapy was administered. The patient has been in remission for 24 months. PPC was confirmed by histo pathology and immunohistochemistry in both cases. Gestational origin of the tumor was confirmed by molecular genetic analysis (polymorphic microsatellite markers).CONCLUSION: The possibility of choriocarcinoma cannot be overlooked in young women with an isolated pulmonary mass. Early diagnosis, prompt chemotherapy, and surgical resection in a specialized center improves the prognosis. (J Reprod Med 2010;55:311-316)en
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, BR-18618970 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, BR-18618970 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Urol,Neogene Lab, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Urol,Neogene Lab, BR-18618970 São Paulo, Brazil
dc.format.extent311-316
dc.identifierhttp://www.reproductivemedicine.com/toc/auto_abstract.php?id=23770
dc.identifier.citationJournal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 55, n. 7-8, p. 311-316, 2010.
dc.identifier.issn0024-7758
dc.identifier.lattes9012667997804219
dc.identifier.lattes2259986546265579
dc.identifier.urihttp://hdl.handle.net/11449/12118
dc.identifier.wosWOS:000280968800008
dc.language.isoeng
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofJournal of Reproductive Medicine
dc.relation.ispartofjcr0.452
dc.relation.ispartofsjr0,270
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgenetic originen
dc.subjectprimary pulmonary choriocarcinomaen
dc.subjectsalvage therapyen
dc.titlePrimary Pulmonary Choriocarcinoma After Human Chorionic Gonadotropin Normalization Following Hydatidiform Mole A Report of Two Casesen
dc.typeArtigo
dcterms.rightsHolderSci Printers & Publ Inc
unesp.author.lattes9012667997804219
unesp.author.lattes2259986546265579
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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