Alcohol extract of Pterogyne nitens leaves fails to reduce severity of streptozotocin-induced diabetes in rats

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dc.contributor.authorde Souza, Aline [UNESP]
dc.contributor.authorVendramini, Regina C. [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorSiqueira Silva, Dulce H. [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorPepato, Maria T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:21:10Z
dc.date.available2014-05-20T14:21:10Z
dc.date.issued2010-05-04
dc.description.abstractTwo constituents of Pterogyne nitens leaves, kaempferitrin, a diglycosylated flavonol, and galegin, a guanidine alkaloid, may be considered likely to exert an antidiabetic effect, on the basis of their chemical structures. Thus, experimentally diabetic rats were treated with P. nitens leaf extract, to observe the effects on biochemical and toxicological marker variables. Streptozotocin-diabetic rats (50 mg/kg body weight) were given ethanolic extract of the leaves (76 mg suspended in 0.5 mL of 10% aqueous glycerine per rat) (DP) by gavage, twice a day for 32 days. Diabetic controls were given 0.5 mL of 10% glycerine (DG), insulin (2.5 U in 0.3 mL s. c.) (DI) or 0.5 ml water (DW). Initial glycemia was 537.11 +/- 10.35 mg/dL. Each week or fortnight after the treatment glucose, urea and protein contents were determined in the urine and glycemia and alkaline phosphatase activity in the serum. Except for proteinuria, the results for groups DP, DG and DW all differed significantly (p < 0.05) from those for group DI, which exhibited reduced values of all the other variables. The plant extract neither improved nor worsened the diabetic state of the rats; nor did it give rise to any hepato-biliary toxic effect.en
dc.description.affiliationSão Paulo State Univ, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Organ Chem, Inst Chem, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Organ Chem, Inst Chem, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipPADC-Araraquara
dc.format.extent802-808
dc.identifierhttp://dx.doi.org/10.5897/JMPR10.094
dc.identifier.citationJournal of Medicinal Plants Research. Victoria Island: Academic Journals, v. 4, n. 9, p. 802-808, 2010.
dc.identifier.doi10.5897/JMPR10.094
dc.identifier.fileWOS000278587700012.pdf
dc.identifier.issn1996-0875
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/26328
dc.identifier.wosWOS:000278587700012
dc.language.isoeng
dc.publisherAcademic Journals
dc.relation.ispartofJournal of Medicinal Plants Research
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntidiabetic planten
dc.subjectalkaline phosphataseen
dc.subjectbiochemical markersen
dc.subjecthepato-biliary toxicity markeren
dc.titleAlcohol extract of Pterogyne nitens leaves fails to reduce severity of streptozotocin-induced diabetes in ratsen
dc.typeArtigo
dcterms.licensehttp://www.academicjournals.org/Creative%20Common%20Attribution%20License.htm
dcterms.rightsHolderAcademic Journals
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Artigos - Química Orgânica - IQ