Clinical findings of equine leukoencephalomalacia

Página do item simplificado
dc.contributor.authorAlbertino, Lukas G. [UNESP]
dc.contributor.authorDias, Natália M. [UNESP]
dc.contributor.authorMoreira, Juliana J. [UNESP]
dc.contributor.authorOliveira-Filho, José P. [UNESP]
dc.contributor.authorTakahira, Regina K. [UNESP]
dc.contributor.authorLaufer-Amorim, Renée [UNESP]
dc.contributor.authorBorges, Alexandre S. [UNESP]
dc.contributor.authorAmorim, Rogério M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:36:40Z
dc.date.available2022-04-29T08:36:40Z
dc.date.issued2021-01-01
dc.description.abstractEquine leukoencephalomalacia (LEM) is a disease caused by the ingestion of food, especially corn, contaminated by fumonisin, a Fusarium verticillioides (synonymous with F. moniliforme) metabolite. The clinical signs of brain injuries have an acute onset and rapid evolution. This study aimed to describe the clinical findings in 11 animals diagnosed with LEM, including cerebrospinal fluid (CSF) analysis. Of these animals, 91% (10/11) were horses, and only 9% (1/11) were asinine. The clinical localization of the lesions was 64% (7/10) cerebral, manifested mainly by altered mental state and behavioral disturbance, and 36% (4/11) were brainstem lesions, manifested by incoordination, head tilt, nystagmus, facial hypoalgesia, difficulty in apprehension, chewing, and swallowing food. Postmortem findings revealed that 82% (9/11) of the lesions were in the cerebrum and 18% (2/11) in the brainstem. CSF findings, such as xanthochromia (43%, 3/7), hyperproteinorrachia (50%, 3/6), and pleocytosis (43%, 3/7) were observed. The affected animals showed neurological signs that were compatible with cerebral and/or brainstem injuries. The CSF from animals with LEM may present with xanthochromia, hyperproteinorrachia, and pleocytosis, reinforcing the fact that this disease should be included in the differential diagnosis of encephalomyelopathies.en
dc.description.affiliationDepartamento de Clínica Veterinária (DCV) Faculdade de Medicina e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Doutor Walter Mauricio Corrêa s/n, Cx. Postal 560, SP
dc.description.affiliationUnespDepartamento de Clínica Veterinária (DCV) Faculdade de Medicina e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Doutor Walter Mauricio Corrêa s/n, Cx. Postal 560, SP
dc.identifierhttp://dx.doi.org/10.1590/1678-5150-PVB-6912
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 41.
dc.identifier.doi10.1590/1678-5150-PVB-6912
dc.identifier.issn1678-5150
dc.identifier.issn0100-736X
dc.identifier.scopus2-s2.0-85119534347
dc.identifier.urihttp://hdl.handle.net/11449/229921
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.sourceScopus
dc.subjectClinical aspects
dc.subjectEpidemiological aspects
dc.subjectEquine
dc.subjectLeukoencephalomalacia
dc.titleClinical findings of equine leukoencephalomalaciaen
dc.typeArtigo

Arquivos

Coleções

Artigos - Clínica Veterinária - FMVZ