Short-term combined training reduces hepatic steatosis and improves hepatic insulin signaling

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dc.contributor.authorPereira, Rodrigo Martins
dc.contributor.authorda Cruz Rodrigues, Kellen Cristina
dc.contributor.authorSant'Ana, Marcella Ramos
dc.contributor.authorPeruca, Guilherme Francisco
dc.contributor.authorAnaruma, Chadi Pellegrini [UNESP]
dc.contributor.authorde Campos, Thaís Dantis Pereira
dc.contributor.authordos Santos Canciglieri, Raphael
dc.contributor.authorde Melo, Diego Gomes
dc.contributor.authorSimabuco, Fernando Moreira
dc.contributor.authorda Silva, Adelino Sanchez Ramos
dc.contributor.authorCintra, Dennys Esper
dc.contributor.authorRopelle, Eduardo Rochete
dc.contributor.authorPauli, José Rodrigo
dc.contributor.authorde Moura, Leandro Pereira
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:47:02Z
dc.date.available2022-04-28T19:47:02Z
dc.date.issued2021-12-15
dc.description.abstractHepatic steatosis is directly associated with hepatic inflammation and insulin resistance, which is correlated with hyperglycemia and type 2 diabetes mellitus (T2DM). Aerobic and strength training have been pointed out as efficient strategies against hepatic steatosis. However, little is known about the effects of the combination of those two protocols on hepatic steatosis. Therefore, this study aimed to evaluate the impact of short-term combined training (STCT) on glucose homeostasis and in the synthesis and oxidation of fat in the liver of obesity-induced mice with hepatic steatosis. Swiss mice were distributed into three groups: control lean (CTL), sedentary obese (OB), and combined training obese (CTO). The CTO group performed the STCT protocol, which consisted of strength and aerobic exercises in the same session. The protocol lasted seven days. The CTO group reduced the glucose levels and fatty liver when compared to the OB group. Interestingly, these results were observed even without reductions in body adiposity. CTO group also showed increased hepatic insulin sensitivity, with lower hepatic glucose production (HGP). STCT reduced the expression of the lipogenic genes Fasn and Scd1 and hepatic inflammation, as well as increased the ACC phosphorylation and the oxidative genes Cpt1a and Ppara, reverting the complications caused by obesity. Since this protocol increased lipid oxidation and reduced hepatic lipogenesis, regardless of body fat mass decrease, it can be considered an effective non-pharmacological strategy for the treatment of hepatic steatosis.en
dc.description.affiliationExercise Cell Biology Lab Faculty of Applied Sciences University of Campinas
dc.description.affiliationLaboratory of Nutritional Genomics Faculty of Applied Sciences University of Campinas
dc.description.affiliationMotricity Sciences Institute of Biosciences São Paulo State University Julio de Mesquita Filho
dc.description.affiliationMultidisciplinary Laboratory of Food and Health Faculty of Applied Sciences University of Campinas
dc.description.affiliationSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School USP
dc.description.affiliationLaboratory of Molecular Biology of Exercise Faculty of Applied Sciences University of Campinas
dc.description.affiliationUnespMotricity Sciences Institute of Biosciences São Paulo State University Julio de Mesquita Filho
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/07199-2
dc.description.sponsorshipIdFAPESP: 2016/12569-6
dc.description.sponsorshipIdFAPESP: 2016/24406-4
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.120124
dc.identifier.citationLife Sciences, v. 287.
dc.identifier.doi10.1016/j.lfs.2021.120124
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.scopus2-s2.0-85118754382
dc.identifier.urihttp://hdl.handle.net/11449/222825
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.sourceScopus
dc.subjectCombined training
dc.subjectDiabetes
dc.subjectHepatic steatosis
dc.subjectInsulin sensitivity
dc.subjectLiver
dc.subjectObesity
dc.titleShort-term combined training reduces hepatic steatosis and improves hepatic insulin signalingen
dc.typeArtigo

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