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Shiitake (Lentinula edodes (Berkeley) Pegler) extracts as a modulator of micronuclei induced in HEp-2 cells

dc.contributor.authorMiyaji, C. K.
dc.contributor.authorPoersch, A.
dc.contributor.authorRibeiro, L. R.
dc.contributor.authorEira, A. F.
dc.contributor.authorColus, I. M. S.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:28:45Z
dc.date.available2014-05-20T15:28:45Z
dc.date.issued2006-12-01
dc.description.abstractShiitake (Lentinula edodes (Berkeley) Pegler) is one of the most consumed mushrooms, for both therapeutic purposes and as food, therefore, the study of its biological properties is of great interest for producers and consumers. Aqueous extracts of the shiitake mushroom (L. edodes (Berkeley) Pegler) were evaluated by the micronucleus test (MN) in HEp-2 cells in vitro, to analyze their possible mutagenic and antimutagenic activities. None of the three extract concentrations tested (0.5, 1.0 and 1.5 mg/mL) presented mutagenicity at any of the preparation temperatures (4 degrees C, 22 +/- 2 degrees C and 60 degrees C). In the antimutagenicity evaluation, all extract concentrations at all preparation temperatures presented a strong protective activity for the HEp-2 cells in response to the alkylating agent methyl methanesulfonate (MMS) in the different treatment protocols: pre-treatment, simultaneous treatment and post-treatment. The extracts prepared at 22 +/- 2 degrees C presented the lowest frequencies of MN in the evaluations of mutagenicity and antimutagenicity, indicating these as the best option for potential therapeutic use. (c) 2006 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Londrina, Dept Biol Geral, CCB, BR-86051970 Londrina, Parana, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, BR-01405 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, BR-01405 São Paulo, Brazil
dc.format.extent1555-1559
dc.identifierhttp://dx.doi.org/10.1016/j.tiv.2006.07.004
dc.identifier.citationToxicology In Vitro. Oxford: Pergamon-Elsevier B.V., v. 20, n. 8, p. 1555-1559, 2006.
dc.identifier.doi10.1016/j.tiv.2006.07.004
dc.identifier.issn0887-2333
dc.identifier.urihttp://hdl.handle.net/11449/38507
dc.identifier.wosWOS:000242136100035
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology in Vitro
dc.relation.ispartofjcr3.105
dc.relation.ispartofsjr0,931
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmicronucleus testpt
dc.subjectLentinula edodespt
dc.subjectShiitakept
dc.subjectmutagenicitypt
dc.subjectantimutagenicitypt
dc.titleShiitake (Lentinula edodes (Berkeley) Pegler) extracts as a modulator of micronuclei induced in HEp-2 cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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