Cytotoxicity and genotoxicity of thymol verified in murine macrophages (RAW 264.7) after antimicrobial analysis in Candida albicans, Staphylococcus aureus, and Streptococcus mutans

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dc.contributor.authorBelato, Kely Karina [UNESP]
dc.contributor.authorde Oliveira, Jonatas Rafael [UNESP]
dc.contributor.authorde Oliveira, Fernanda Saraiva [UNESP]
dc.contributor.authorde Oliveira, Luciane Dias [UNESP]
dc.contributor.authorCamargo, Samira Esteves Afonso [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:50:47Z
dc.date.available2018-12-11T16:50:47Z
dc.date.issued2018-01-01
dc.description.abstractThymol is a phytocompound present in many plants and several biological effects have been reported, such as antimicrobial effect. However, the biocompatibility of this plant product should be checked. Thereby, the action of thymol was evaluated in C. albicans, S. aureus, and S. mutans, as well as in murine macrophages (RAW 264.7). Firstly, the effect of thymol was analyzed in planktonic cultures of microorganisms and the most effective concentration was evaluated in biofilms. Cytotoxicity, quantification of TNF-α and genotoxicity were checked. The results were analyzed by T-Test or ANOVA and Tukey's Test (P ≤ .05). Thymol provided inhibitory and microbicidal effects for planktonic cultures and reduction of biofilms. High concentrations affected the viability of RAW 264.7. Production of TNF-α and frequency of micronuclei were similar to the control group. Thus, thymol showed antimicrobial effect, biocompatibility in some concentrations and absence of genotoxicity.en
dc.description.affiliationSão Paulo State University (UNESP) Institute of Science and Technology Department of Biosciences and Oral Diagnosis, Av. Engenheiro Francisco José Longo, 777 – Jardim São Dimas
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Science and Technology Department of Biosciences and Oral Diagnosis, Av. Engenheiro Francisco José Longo, 777 – Jardim São Dimas
dc.format.extent455-460
dc.identifierhttp://dx.doi.org/10.1016/j.jff.2017.11.035
dc.identifier.citationJournal of Functional Foods, v. 40, p. 455-460.
dc.identifier.doi10.1016/j.jff.2017.11.035
dc.identifier.file2-s2.0-85035801341.pdf
dc.identifier.issn1756-4646
dc.identifier.scopus2-s2.0-85035801341
dc.identifier.urihttp://hdl.handle.net/11449/170434
dc.language.isoeng
dc.relation.ispartofJournal of Functional Foods
dc.relation.ispartofsjr1,245
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntimicrobial activity
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectThymol
dc.subjectTNF-α
dc.titleCytotoxicity and genotoxicity of thymol verified in murine macrophages (RAW 264.7) after antimicrobial analysis in Candida albicans, Staphylococcus aureus, and Streptococcus mutansen
dc.typeArtigo
unesp.author.orcid0000-0003-2398-6506[2]

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