Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo

Página do item simplificado
dc.contributor.authorOliveira-Caramez, Maria Luiza de
dc.contributor.authorVeiga-Castelli, Luciana
dc.contributor.authorSouza, Andreia S. [UNESP]
dc.contributor.authorCardili, Renata Nahas
dc.contributor.authorCourtin, David
dc.contributor.authorFlória-Santos, Milena
dc.contributor.authorDonadi, Eduardo
dc.contributor.authorGiuliatti, Silvana
dc.contributor.authorSabbagh, Audrey
dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorMendes-Junior, Celso Teixeira
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversité de Paris
dc.date.accessioned2023-07-29T14:00:48Z
dc.date.available2023-07-29T14:00:48Z
dc.date.issued2023-02-01
dc.description.abstractVitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many with immunological functions. Among them is HLA-G, which modulates immunity by interacting with specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated the LILRB1 and LILRB2 association with vitiligo risk and evaluated the possible role of interactions between HLA-G and its receptors in this pathogenesis. We tested the association of the polymorphisms of HLA-G, LILRB1, and LILRB2 with vitiligo using logistic regression along with adjustment by ancestry. Further, methods based on the multifactor dimensionality reduction (MDR) approach (MDR v.3.0.2, GMDR v.0.9, and MB-MDR) were used to detect potential epistatic interactions between polymorphisms from the three genes. An interaction involving rs9380142 and rs2114511 polymorphisms was identified by all methods used. The polymorphism rs9380142 is an HLA-G 3′UTR variant (+3187) with a well-established role in mRNA stability. The polymorphism rs2114511 is located in the exonic region of LILRB1. Although no association involving this SNP has been reported, ChIP-Seq experiments have identified this position as an EBF1 binding site. These results highlight the role of an epistatic interaction between HLA-G and LILRB1 in vitiligo pathogenesis.en
dc.description.affiliationDepartamento de Genética Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SP
dc.description.affiliationMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University (UNESP), SP
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SP
dc.description.affiliationInstitut de Recherche pour le Développement UMR 261 MERIT Université de Paris
dc.description.affiliationDepartamento de Enfermagem Materno-Infantil e Saúde Pública—(EERP/ERM) Universidade de São Paulo, SP
dc.description.affiliationPathology Department School of Medicine São Paulo State University (UNESP), SP
dc.description.affiliationLaboratório de Pesquisas Forenses e Genômicas Departamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, SP
dc.description.affiliationUnespMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University (UNESP), SP
dc.description.affiliationUnespPathology Department School of Medicine São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.3390/cells12040630
dc.identifier.citationCells, v. 12, n. 4, 2023.
dc.identifier.doi10.3390/cells12040630
dc.identifier.issn2073-4409
dc.identifier.scopus2-s2.0-85148862002
dc.identifier.urihttp://hdl.handle.net/11449/249042
dc.language.isoeng
dc.relation.ispartofCells
dc.sourceScopus
dc.subjectancestry
dc.subjectBrazil
dc.subjectILT-2
dc.subjectILT-4
dc.subjectLILRB2
dc.subjectSNPforID
dc.titleEvidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligoen
dc.typeArtigo
unesp.author.orcid0000-0002-8155-0244[1]
unesp.author.orcid0000-0002-6853-1559[3]
unesp.author.orcid0000-0002-0656-1736[6]
unesp.author.orcid0000-0002-7520-6420[8]
unesp.author.orcid0000-0002-7337-1203[11]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentEnfermagem - FMBpt

Arquivos

Coleções

Botucatu - FMB - Faculdade de Medicina