Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models

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Nwidu, Lucky Lebgosi
Nwafor, Paul Alozie
Da Silva, Viviane Cândida [UNESP]
Rodrigues, Clenilson Martins [UNESP]
Santos, Lourdes Campaner dos [UNESP]
Vilegas, Wagner [UNESP]
Nunes-De-Souza, Ricardo Luiz [UNESP]
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Leaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects of Carpolobia lutea (CL) G. Don (Polygalaceae) organic leaf extracts were tested in experimental models in mice. The anti-nociceptive mechanism was determined using tail-flick test, acetic acid-induced abdominal constrictions, formalin-induced hind paw licking and the hot plate test. The fractions (ethanol, ethyl acetate, chloroform, n-hexane) and crude ethyl acetate extract of CL (770 mg/kg, i.p.) produced significant inhibitions of both phases of the formalin-induced pain in mice, a reduction in acetic acid-induced writhing as well as and an elevation of the pain threshold in the hot plate test in mice. The inhibitions were greater to those produced by indomethacin (5 mg/kg, i.p.). Ethyl acetate fraction revealed cinnamic and coumaric acids derivatives, which are described for the first time in literature. These cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities. These findings confirm its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms. © 2011 Springer Basel AG.
Antinociceptive, Carpolobia lutea, HPLC isolation of cinnamalglucosides, Polygalaceae, 4 coumaroyl 1 deoxyglucopyranoside derivative, acetic acid, acetic acid ethyl ester, alcohol, antinociceptive agent, atropine, Carpolobia lutea extract, chloroform, cinnamic acid, cinnamic acid derivative, cinnamoyl 1 deoxyglucopyranoside derivative, coumaric acid, dimorf, formaldehyde, hexane, indometacin, morphine sulfate, naltrexone, plant extract, unclassified drug, abdominal pain, analgesic activity, animal experiment, animal model, antinociception, controlled study, drug isolation, drug screening, drug structure, female, foot pain, hot plate test, licking, male, mouse, nonhuman, pain, pain threshold, plant leaf, priority journal, tail flick test, writhing test, Abdominal Pain, Analgesics, Non-Narcotic, Animals, Anti-Inflammatory Agents, Non-Steroidal, Behavior, Animal, Cinnamates, Coumaric Acids, Drug Discovery, Female, Glucosides, Hot Temperature, Lethal Dose 50, Male, Medicine, African Traditional, Mice, Molecular Structure, Nigeria, Pain Measurement, Plant Extracts, Plant Leaves
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Inflammopharmacology, v. 19, n. 4, p. 215-225, 2011.