New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery

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dc.contributor.authorSábio, Rafael M.
dc.contributor.authorMeneguin, Andréia B.
dc.contributor.authorRibeiro, Taís C. [UNESP]
dc.contributor.authorSilva, Robson R.
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T17:07:56Z
dc.date.available2019-10-06T17:07:56Z
dc.date.issued2019-06-10
dc.description.abstractMesoporous silica nanoparticles (MSNs)displays interesting properties for biomedical applications such as high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of large amounts of drugs, protecting them from deactivation and degradation processes acting as an excellent nanoplatform for drug delivery. However, the functional MSNs do not present the ability to transport the therapeutics without any leakage until reach the targeted cells causing side effects. On the other hand, the hydroxyls groups available on MSNs surface allows the conjugation of specific molecules which can binds to the overexpressed Enhanced Growth Factor Receptor (EGFR)in many tumors, representing a potential strategy for the cancer treatment. Beyond that, the targeting molecules conjugate onto mesoporous surface increase its cell internalization and act as gatekeepers blocking the mesopores controlling the drug release. In this context, multifunctional MSNs emerge as stimuli-responsive controlled drug delivery systems (CDDS)to overcome drawbacks as low internalization, premature release before to reach the region of interest, several side effects and low effectiveness of the current treatments. This review presents an overview of MSNs fabrication methods and its properties that affects drug delivery as well as stimuli-responsive CDDS for cancer treatment.en
dc.description.affiliationSão Carlos Institute of Physics – University of São Paulo (USP)
dc.description.affiliationSchool of Pharmaceutical Sciences – São Paulo State University (UNESP)
dc.description.affiliationDepartment of Chemistry and Chemical Engineering – Chalmers University of Technology
dc.description.affiliationUnespSchool of Pharmaceutical Sciences – São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipStiftelsen för Strategisk Forskning
dc.description.sponsorshipIdStiftelsen för Strategisk Forskning: RMA15–0052
dc.format.extent379-409
dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2019.04.067
dc.identifier.citationInternational Journal of Pharmaceutics, v. 564, p. 379-409.
dc.identifier.doi10.1016/j.ijpharm.2019.04.067
dc.identifier.issn1873-3476
dc.identifier.issn0378-5173
dc.identifier.scopus2-s2.0-85064658091
dc.identifier.urihttp://hdl.handle.net/11449/190277
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCancer
dc.subjectChemotherapy drugs
dc.subjectDrug delivery
dc.subjectMesoporous silica nanoparticles
dc.subjectStimuli-responsive nanoplatforms
dc.titleNew insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs deliveryen
dc.typeResenha
unesp.author.orcid0000-0002-6698-0545[5]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas